“Acute lung injury is a critical respiratory condition caused by various non cardiogenic factors, with poor clinical prognosis. Modern research has revealed mitochondrial dysfunction and reprogramming of glucose metabolism in macrophages, manifested as excessive glycolysis, driving their pro-inflammatory polarization, which is a key mechanism leading to excessive inflammatory response and disease progression in ALI. Researchers have explored the relationship between spleen deficiency and macrophage glycolysis from the perspective of the theory of "spleen not dispersing essence", opening up a new direction for the integrated treatment of ALI with traditional Chinese and Western medicine.”