“The prevention and treatment of breast cancer is a major global public health challenge. As a key pathological transition period, precancerous lesions (PBC) have a significant risk of clinical transformation. Abnormal angiogenesis is the core mechanism driving its malignant transformation, and vascular endothelial growth factor (VEGF) plays a pivotal role in this process. In recent years, studies have found that VEGF forms a complex regulatory network through multiple signaling pathways such as PI3K/Akt, MAPK, HIF-1 α/VEGF, and DLL4/Notch1, mediating PBC angiogenesis. With the characteristics of multi-component synergy, multi-channel regulation and high safety, Chinese medicine has significant advantages in targeting the inhibition of VEGF signaling pathway and blocking the progress of PBC. This paper introduces the research progress of Chinese medicine in the prevention and treatment of precancerous lesions of breast cancer, and provides a solution for the optimization of clinical early intervention strategies.”