“The Republic of China period was a critical stage for the scientific and systematic reconstruction of traditional Chinese herbal knowledge under the impact of Western medicine. The understanding and treatment of toxic traditional Chinese medicine also showed the characteristics of integrating Chinese and Western medicine, and connecting ancient and modern times. This article introduces the research progress in the scientific field of toxic traditional Chinese medicine knowledge, and relevant scholars have established a knowledge system of "recognizing, using, controlling, and detoxifying", providing guidance and reference for the rational use of modern toxic traditional Chinese medicine.”