“The treatment of colorectal cancer faces challenges such as high recurrence rates and drug resistance, and traditional Chinese medicine has shown unique potential with its multi-target advantages. The expert system has sorted out the molecular regulatory mechanism of the Hedgehog signaling pathway in colorectal cancer, with a focus on analyzing the specific mechanism by which the effective ingredients and formulas of traditional Chinese medicine exert anti-cancer effects by intervening in the Hedgehog GLI signaling axis. This provides innovative theoretical basis and practical guidance for the prevention and treatment of colorectal cancer with traditional Chinese medicine.”