“The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls the internal homeostasis of the brain and plays a core role in regulating the blood-brain flux of endogenous and exogenous drugs and related metabolites. This article introduces its research progress in the field of ischemic stroke treatment. The research team has sorted out the mechanism of traditional Chinese medicine monomers, formulas, and preparations in protecting the blood-brain barrier by targeting brain microvascular endothelial cells, opening up new directions for the mechanism research and endovascular treatment of ischemic stroke.”