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Polydatin Delays Progression of Colitis-associated Colorectal Cancer by Modulating IL-17A/Wnt/β-catenin Signaling Pathway
Updated：2026-05-29
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    • Polydatin Delays Progression of Colitis-associated Colorectal Cancer by Modulating IL-17A/Wnt/β-catenin Signaling Pathway

    • “Tiger cane glycoside can inhibit the secretion of IL-17A and the expression of IL-17RA, while improving the immune microenvironment, blocking the Wnt/β - catenin signaling pathway and the expression of epithelial mesenchymal transition markers, restoring the expression of tight junction proteins in the intestinal epithelium, and delaying the progression of colitis to colon cancer in mice. The research team established a colitis related colon cancer mouse model and explored the role and potential mechanism of tiger cane glycoside in delaying the progression of CAC, providing new ideas for the prevention and treatment of colon cancer.”
    • LIU Jie , LYU Mengmeng , HONG Yanfei , NAN Xinmei , SU Jialong , LIU Huachen , WANG Qing , PENG Guiying
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 13, Pages: 144-154(2026)

    • DOI： 10.13422/j.cnki.syfjx.20252129     

      CLC：

    • Revised：2025-10-21 ，

      Accepted：22 October 2025 ，

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