Effect and Action Mechanism of Huazhuo Sanjie Chubi Prescription on Gouty Bone Erosion Model Rats Based on PI3K/Akt Signaling Pathway

ZHENG Zhuoming; LIU Jun; WANG Meiling; CHEN Xiaohua; LI Yuwan; PENG Siwei; ZHANG Yingjie; YANG Ruifang; SU Youxin; XIAO Yan; GUO Jiemei

doi:10.13422/j.cnki.syfjx.20252325

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Effect and Action Mechanism of Huazhuo Sanjie Chubi Prescription on Gouty Bone Erosion Model Rats Based on PI3K/Akt Signaling Pathway

Updated：2026-03-03

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- Effect and Action Mechanism of Huazhuo Sanjie Chubi Prescription on Gouty Bone Erosion Model Rats Based on PI3K/Akt Signaling Pathway
- “Huazhuo San Jie Qu Bi Fang has significant therapeutic effects on gout bone erosion model rats, which can reduce serum uric acid levels, decrease the secretion of inflammatory factors, and downregulate the expression of bone erosion related proteins. Its mechanism may be related to the inhibition of the PI3K/Akt signaling pathway.”
- ZHENG Zhuoming , LIU Jun , WANG Meiling , CHEN Xiaohua , LI Yuwan , PENG Siwei , ZHANG Yingjie , YANG Ruifang , SU Youxin , XIAO Yan , GUO Jiemei
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 7, Pages: 105-117(2026)
- Affiliations：
  1.The First Clinical Medical College，Fujian University of Traditional Chinese Medicine（TCM）， Fuzhou 350004，China
  2.School of Orthopedics and Traumatology， Fujian University of TCM， Fuzhou 350122，China
  3.Key Laboratory of Orthopedics & Traumatology of TCM and Rehabilitation，Ministry of Education，Fuzhou 350122，China
- Author bio：
- Funds：
- DOI： 10.13422/j.cnki.syfjx.20252325
  CLC：
- Revised：2025-10-25 ，
  Accepted：31 October 2025 ，
- Accepted：
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Related Author

ZHENG Zhuoming

LIU Jun

WANG Meiling

CHEN Xiaohua

LI Yuwan

PENG Siwei

ZHANG Yingjie

YANG Ruifang

Related Institution

The First Clinical Medical College，Fujian University of Traditional Chinese Medicine

School of Orthopedics and Traumatology，Fujian University of Traditional Chinese Medicine

Key Laboratory of Orthopedics & Traumatology of Traditional Chinese Medicine and Rehabilitation，Ministry of Education

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM），Tianjin/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

Graduate School of Tianjin University of TCM