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Mechanistic Study on Effect of Cycloastragenol in Improving Mitochondrial Function and Inhibiting Cardiac Remodeling via GPCR/cAMP/PKA/CREB Signaling Pathway
Updated:2026-09-17
    • Mechanistic Study on Effect of Cycloastragenol in Improving Mitochondrial Function and Inhibiting Cardiac Remodeling via GPCR/cAMP/PKA/CREB Signaling Pathway

    • “Huangqi alcohol can activate the ADRB2 mediated GPCR/cAMP/PKA/CREB signaling pathway, enhance PGC-1 α/NRF1/TFAM activity, promote mitochondrial energy metabolism reconstruction, inhibit oxidative stress, inflammation, and myocardial fibrosis, thereby delaying adverse cardiac remodeling and improving cardiac function. The research progress in the field of heart failure treatment was introduced. The research team established a rat heart failure model to explore the mechanism of CAG intervention, providing a new solution for the development of myocardial protective drugs.”
    • WEI Dongsheng , ZHAO Menglan , GU Wenhao , LIANG Jinpu , LIU Yu , ZHANG Xiaoqing
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 20, Pages: 112-121(2026)
    • DOI: 10.13422/j.cnki.syfjx.20260208     

      CLC:
    • Revised:2026-01-29 ,

      Accepted:24 February 2026 ,

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