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Mechanistic Study on Effect of Cycloastragenol in Improving Mitochondrial Function and Inhibiting Cardiac Remodeling via GPCR/cAMP/PKA/CREB Signaling Pathway
Mechanistic Study on Effect of Cycloastragenol in Improving Mitochondrial Function and Inhibiting Cardiac Remodeling via GPCR/cAMP/PKA/CREB Signaling Pathway
- “Huangqi alcohol can activate the ADRB2 mediated GPCR/cAMP/PKA/CREB signaling pathway, enhance PGC-1 α/NRF1/TFAM activity, promote mitochondrial energy metabolism reconstruction, inhibit oxidative stress, inflammation, and myocardial fibrosis, thereby delaying adverse cardiac remodeling and improving cardiac function. The research progress in the field of heart failure treatment was introduced. The research team established a rat heart failure model to explore the mechanism of CAG intervention, providing a new solution for the development of myocardial protective drugs.”
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 20, Pages: 112-121(2026)
DOI: 10.13422/j.cnki.syfjx.20260208
Revised:2026-01-29 ,
Accepted:24 February 2026
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Related Author
ZHOU Junlin
ZHANG Xiaojiao
CHEN Jiahui
LIN Liyu
ZHANG Shiyin
CHEN Yiyi
DONG Xiaoming
LONG Wenjie
Related Institution
State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Affiliated Hospital of Guangzhou University of Chinese Medicine
The First Clinical Medical College, Guangzhou University of Chinese Medicine
The First Affiliated Hospital of Henan University of Chinese Medicine
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine
Henan University of Chinese Medicine


