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Investigation on Pharmacodynamic Material Basis of Linggui Zhugan Granules for Metabolic Associated Steatohepatitis Based on UPLC-Q-TOF-MS/MS
Updated：2026-08-06
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    • Investigation on Pharmacodynamic Material Basis of Linggui Zhugan Granules for Metabolic Associated Steatohepatitis Based on UPLC-Q-TOF-MS/MS

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    • “The research team used UPLC-Q-TOF-MS/MS technology to identify 83 chemical components in Linggui Zhugan granules, established a "compound disease component target" network analysis system, and verified the pharmacological mechanism of flavonoids and terpenoids in treating metabolic related steatohepatitis by regulating the AMPK/SIRT1/PPAR α signaling pathway, opening up a new direction for the research on the pharmacological substance basis of traditional Chinese medicine compound.”
    • YAO Chiyan , LI Liang , YAN Ming , WANG Zhenzhong , ZHANG Chenfeng , LI Ming , XIE Xue
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 17, Pages: 228-238(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260462     

      CLC：

    • Revised：2026-03-31 ，

      Accepted：20 April 2026 ，

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