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Modified Xiaoyaosan Alleviates Neuronal Dysfunction in Rat Model of Post-myocardial Infarction Depression by Regulating Mitochondrial Quality Control Through Drp1/PINK1/Parkin Signaling Pathway
Updated：2026-05-29
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    • Modified Xiaoyaosan Alleviates Neuronal Dysfunction in Rat Model of Post-myocardial Infarction Depression by Regulating Mitochondrial Quality Control Through Drp1/PINK1/Parkin Signaling Pathway

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    • “Modified Xiaoyao Powder can significantly improve depression like behavior and neurotransmitter imbalance in rats with depression after myocardial infarction. Its effect may be related to regulating hippocampal mitochondrial quality control and upregulating Drp1/PINK1/Parkin related signaling pathways, providing experimental evidence for the intervention of modified Xiaoyao Powder in depression after myocardial infarction. The research progress in the field of traditional Chinese medicine antidepressant was introduced. The research team established a rat model of myocardial infarction depression and explored the intervention mechanism of modified Xiaoyao Powder, providing experimental evidence for the traditional Chinese medicine treatment of depression after myocardial infarction.”
    • ZHONG Zhen , WEI Dongsheng , XIONG Xinyue , LI Lin , YAO Mingli , SHI Xinnuan , JIANG Youming
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 13, Pages: 20-31(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260518     

      CLC：

    • Revised：2026-04-14 ，

      Accepted：21 April 2026 ，

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