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Exploring Antidepressant Mechanism of Kaixin San by Regulating 5-Hydroxytryptamine System in Gut-brain Axis Based on Fecal Metabolomics
Updated：2026-07-01
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    • Exploring Antidepressant Mechanism of Kaixin San by Regulating 5-Hydroxytryptamine System in Gut-brain Axis Based on Fecal Metabolomics

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    • “Kaixin San significantly improved depression like behavior in CRS mice, and its antidepressant mechanism is related to regulating the fecal metabolome and improving the gut brain axis 5-HT system. The research team investigated the changes in the serotonin system in the gut brain axis based on fecal metabolomics analysis, explored the antidepressant mechanism of Kaixin San, and opened up new directions for traditional Chinese medicine antidepressant research.”
    • DONG Ai , BAI Yunfeng , LI Chenglin , TANG Yanan , WANG Chunguo , XU Yantong
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 15, Pages: 57-66(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260566     

      CLC：

    • Revised：2026-05-20 ，

      Accepted：21 May 2026 ，

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