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Gardeniae Fructus-Salviae Miltiorrhizae Radix et Rhizoma Regulates Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway to Alleviate Myocardial Remodeling in Rat Model of Myocardial Infarction
Updated：2026-09-17
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    • Gardeniae Fructus-Salviae Miltiorrhizae Radix et Rhizoma Regulates Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway to Alleviate Myocardial Remodeling in Rat Model of Myocardial Infarction

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    • “Gardenia and Danshen alleviate pathological damage and myocardial remodeling in rats with myocardial infarction by inhibiting myocardial iron death. Its mechanism of action is related to the activation of the Nrf2/SLC7A11/GPX4 signaling pathway. The research team has established an experimental system for regulating iron death and intervening in myocardial remodeling with traditional Chinese medicine, opening up new directions for research on myocardial protection after myocardial infarction.”
    • CHEN Xuesong , QIU Rongnan , WANG Shenghao , FENG Yan , XIE Jutong , YAN Yuwen , YANG Tianlin , XIE Changxu , GAO Lei , SHEN Jianping , SHEN Yuehong
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 20, Pages: 54-62(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260632     

      CLC：

    • Revised：2026-03-20 ，

      Accepted：23 March 2026 ，

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Related Author

YANG Xiaoyu
NING Zixin
LIU Ying
LEI Tong
SHEN Li
YANG Jianfei
LIN Huanhuan
SHI Xiaoli

Related Institution

Institute of Basic Theory for Chinese Medicine， China Academy of Chinese Medical Sciences
School of Clinical Medicine，Gansu University of Chinese Medicine
The First Affiliated Hospital of Gansu University of Chinese Medicine
College of Traditional Chinese Medicine， Shandong University of Traditional Chinese Medicine
Postdoctoral Mobile Workstation，Shandong University of Traditional Chinese Medicine