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Mechanism of Chidamide Combined with Compound Kushen Injection on Breast Cancer Cells Based on Transcriptomics
Updated:2026-08-06
    • Mechanism of Chidamide Combined with Compound Kushen Injection on Breast Cancer Cells Based on Transcriptomics

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    • “The combination of Sidabenamide and Compound Sophora flavescens injection can synergistically inhibit breast cancer MCF-7 cells. The "One Belt and One Line" method is used to screen the best synergetic concentration. Its mechanism involves HDAC1 inhibition and cAMP/PKA/CREB pathway activation, which opens up a new direction for the research of combined drugs for breast cancer.”
    • BI Yanxing , LI Yuning , LI Ge , CUI Wenping , YANG Xiaolai
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 17, Pages: 134-143(2026)
    • DOI: 10.13422/j.cnki.syfjx.20260665     

      CLC:
    • Revised:2026-05-09 ,

      Accepted:02 June 2026 ,

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