“Mitochondrial autophagy, as the core mechanism of mitochondrial quality control, can selectively identify and eliminate damaged mitochondria, effectively reduce ROS accumulation and energy metabolism disorders, and maintain the balance of osteogenic osteoclast differentiation. This article introduces its research progress in the field of osteoporosis prevention and treatment. Experts have established a correlation system between the theory of "deficiency qi retention" and mitochondrial autophagy, opening up new directions for traditional Chinese medicine in the prevention and treatment of primary osteoporosis.”