“Dilated cardiomyopathy has a very poor prognosis, and existing Western medicine treatments are difficult to reverse myocardial injury. In recent years, research has confirmed that sustained overactivation of endoplasmic reticulum stress is one of the key pathological hubs mediating myocardial injury in this disease, and has become a highly promising new intervention target in the field of treatment. This article introduces its research progress in the field of traditional Chinese medicine, systematically expounds the core regulatory pathway of ER stress, deeply analyzes the key mechanism of its mediating pathological progress, and emphatically summarizes the latest basic research progress of targeted regulation of ER stress treatment of this disease such as Chinese herbal compound, single and active extracts, traditional Chinese patent medicines and simple preparations, which provides theoretical support and research ideas for the precise prevention and treatment of dilated cardiomyopathy with traditional Chinese medicine.”