“Programmed cell death (PCD) is a process of autonomous cell death precisely regulated by genes, which is essential to maintain the homeostasis of the intracellular environment. This paper introduces its research progress in the field of pancreatic cancer. Experts systematically summarized the molecular mechanism of PCD in the progress of PC, and summarized the mechanism of Chinese herbal compound and natural active ingredients intervening in the progress of PC by regulating PCD, providing theoretical support and research direction for Chinese medicine to prevent and treat pancreatic cancer.”