“Based on the "plaster turbid theory" of traditional Chinese medicine and the "skin gut axis" theory of modern medicine, this paper systematically discusses the evolution law of the pathogenesis of DU in traditional Chinese medicine and the internal relationship between it and the imbalance of microecology, further proposes the potential strategy of traditional Chinese medicine intervention, and the research team has constructed a theoretical framework of integrated traditional Chinese and western medicine for the prevention and treatment of diabetes ulcers, opening up a new direction for clinical practice and follow-up research.”