“The Tengli anti-tumor formula can significantly improve the quality of life of AOM/DSS induced CRA model mice, reduce intestinal inflammation, decrease the number and size of colorectal tumors, and delay the progression of tumor like lesions. Its mechanism may be achieved by inhibiting the activation of the STAT3/p-STAT3 signaling pathway, targeting M2 macrophages, improving the tumor microenvironment, and thus inhibiting CRA carcinogenesis. The research progress in the field of colorectal cancer prevention and treatment was introduced. The research team explored the intervention mechanism of traditional Chinese medicine compound targeting the tumor microenvironment, providing a new strategy for the prevention and treatment of colorectal adenoma carcinogenesis.”