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1.江苏大学 药学院,食品与生物工程学院,江苏 镇江 212013
2.中国中医科学院 中药资源中心,北京 100700
Published:20 May 2022,
Published Online:09 November 2021,
Received:07 September 2021,
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杜文敏,詹志来,万晶琼等.经典名方中桑类药材的本草考证[J].中国实验方剂学杂志,2022,28(10):11-21.
DU Wen-min,ZHAN Zhi-lai,WAN Jing-qiong,et al.Herbal Textual Research on Mori in Famous Classical Formulas[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(10):11-21.
杜文敏,詹志来,万晶琼等.经典名方中桑类药材的本草考证[J].中国实验方剂学杂志,2022,28(10):11-21. DOI: 10.13422/j.cnki.syfjx.20212149.
DU Wen-min,ZHAN Zhi-lai,WAN Jing-qiong,et al.Herbal Textual Research on Mori in Famous Classical Formulas[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(10):11-21. DOI: 10.13422/j.cnki.syfjx.20212149.
通过查阅历代本草、医籍、方书等古代资料,笔者结合现代文献对桑类药材(桑叶、桑白皮、桑枝、桑椹)的名称、基原、产地、质量评价、采收加工及炮制方法等进行全面梳理和综合考证,为含该类药材经典名方的开发提供依据。经考证可知,桑叶、桑白皮入药始载于《神农本草经》,桑枝入药始载于《近效方》,桑椹入药始载于《新修本草》。唐以前,本草书籍记载桑有山桑与女桑之分;自唐代以后,桑类药材基原有白桑、鸡桑、山桑等,经考证,历代主流基原品种为鸡桑
Morus australis
、桑
M. alba
及其栽培变种;近现代以来相关资料及历版《中华人民共和国药典》收载桑类药材正品基原均为桑科植物桑
M. alba
。古代时桑树产地随桑蚕业的发展而变迁,从宋代起桑树被广泛种植;明清时期江浙地区生长最多;近代主产于江苏、浙江、安徽、湖南等地。近几年,由于“东蚕西移”等相关政策及战略,桑蚕养殖业的中心逐渐向西部转移。关于桑类药材的质量评价和采收加工,桑叶药材古今记载大多一致,为经霜后采收,除去杂质晒干,质量以叶大而厚、黄绿色、握之刺手且经霜者为佳;桑白皮的采收时期古今记载略有差异,古籍记载其一年四季均可采收,现代多为秋末至次春时期采收,加工方法有除去泥土及须根,刮去黄棕色粗皮,剥取白皮,晒干,质量以色白、皮厚、质柔韧、无粗皮、粉性足者为佳。关于桑枝和桑椹的采收加工和质量评价,历代本草书籍中有关记载较少,综合现代文献所述,桑枝多在春末夏初采收,去叶,略晒,趁鲜切片,晒干,质量以枝细质嫩、断面黄白色者为佳。桑椹为4—6月果实变红时采收,晒干,或略蒸后晒干,以个大、色暗紫、质油润、肉厚者为佳。桑类药材炮制方法较多,古籍记载桑叶有炒法、焙法、烧法、炙法、蒸法等,现代有蜜炙法,但多数为生品入药;古代本草中桑白皮有烧制法、焙制法、炒制法,蜜炙法等,现代有清炒法和蜜炙法,多以生品入药;古籍记载桑枝有切制、炒制法,现代可分为切制、炒制、酒制、麸制;桑椹炮制方法古今一致,多为净制后晒干或蒸后晒干。基于考证结果,建议经典名方中所用桑类药材可选取桑科植物桑
M. alba
,根据方义主治选用合适的药用部位及炮制方法。
Through consulting the ancient herbs, medical books and modern literature, this paper made textual research on the name, origin, producing area, quality evaluation, collection and processing of medicinal materials of Sang (Mori Folium, Mori Cortex, Mori Ramulus, Mori Fructus) in famous classical formulas, in order to provide a basis for the development of famous classical formulas containing medicinal materials of Sang. According to the research, Mori Folium and Mori Cortex were first used as medicines in
Shengnong Bencaojing
, Mori Ramulus was first used as medicine in
Jinxiaofang
, and Mori Fructus was first used as medicine in
Xinxiu Bencao
. Before the Tang dynasty, there were Nyusang and Shansang. Since Tang dynasty, there were many sources of medicinal materials of Sang, including Baisang (
Morus alba
), Jisang (
M. australis
), Shansang (
M. mongolica
), etc. According to textual research, the mainstream varieties were
M. australis
,
M. alba
and their cultivated varieties. In modern times, according to the relevant information and the
Chinese Pharmacopoeia
,
M. alba
is the original base. In ancient times, the origin of mulberry changed with the development of sericulture, mulberry has been widely planted since the Song dynasty. In the Ming and Qing dynasties, mulberry has been planted most in Jiangsu and Zhejiang. In modern times, they are mainly produced in Jiangsu, Zhejiang, Anhui, Hunan and other places. In recent years, due to the related policies and strategies such as "moving silkworms from east to west", the center of silkworm breeding has gradually transferred to the west. As for the quality evaluation and harvesting and processing of mulberry medicinal materials, Most of the ancient and modern records of Mori Folium are the same. They are harvested after frost, and dried after removing impurities. The quality is better when the leaves are large and thick, yellowish green, holding prickly hands and undergoing frost. The harvesting period of Mori Cortex is slightly different in ancient and modern records. Ancient books record that it can be harvested all the year round, but in modern times, it is mostly harvested from late autumn to the next spring. The processing methods include removing soil and fibrous roots, scraping off yellow-brown rough skin, peeling off white skin and drying in the sun. The quality is better when they are white, thick, flexible, free of rough skin and full of powder. There are few records about the collection, processing and quality evaluation of Mori Ramulus and Mori Fructus in ancient Chinese herbal books. According to modern literature, Mori Ramulus is usually collected in late spring and early summer, with leaves removed, slightly dried, sliced while fresh, and dried in the sun. The best quality of Mori Ramulus is fine and tender with the yellow and white section. Mori Fructus is harvested from April to June when the fruit turns red, and dried in the sun, or slightly steamed and dried in the sun, and it is better to be big, dark purple, oily and thick. There are many processing methods of mulberry medicinal materials. Ancient books record stir frying, baking, burning and steaming of Mori Folium, in modern times, there is honey-roasted method, but most of them are used as raw products. In ancient materia medica, Mori Cortex has firing method, baking method, stir-frying method, honey-fried method, etc. In modern times, there are stir-fried and honey-fried methods, and most of them are used as raw products. Ancient books record that Mori Ramulus has cutting and frying methods, while modern ones have cutting, frying, wine-processed and bran-processed methods. Processing methods of Mori Fructus are consistent in ancient and modern times, and they are mostly dried after being cleaned or steamed. Based on the research results, it is suggested that
M.
alba should be selected as mulberry medicinal materials in the famous classical formulas, and appropriate medicinal parts and processing methods can be selected according to the indications of the famous classical formulas.
经典名方桑叶桑白皮桑枝桑椹本草考证质量评价
famous classical formulasMori FoliumMori CortexMori RamulusMori Fructusherbal textual researchquality evaluation
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