Vessel-collateral Theory Guided Rules of Syndrome and Treatment of Cardiovascular Event Chain Based on Medical Record Data Mining and Analysis

Yujie YIN; Liping CHANG; Yao ZHU; Zhenhua JIA

doi:10.13422/j.cnki.syfjx.20220651

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Vessel-collateral Theory Guided Rules of Syndrome and Treatment of Cardiovascular Event Chain Based on Medical Record Data Mining and Analysis

更新时间：2022-08-11

- Vessel-collateral Theory Guided Rules of Syndrome and Treatment of Cardiovascular Event Chain Based on Medical Record Data Mining and Analysis
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 18, Pages: 144-151(2022)
- 作者机构：
  
  1.络病研究与创新中药国家重点实验室，石家庄 050035
  2.国家中医药管理局重点研究室（心脑血管络病），石家庄 050035
  3.河北省中西医结合医药研究院，石家庄 050091
  4.南京中医药大学，南京 210029
  5.河北以岭医院，石家庄 050091
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20220651
  CLC： R22;R24;R931;N37
- Published：20 September 2022，
  
  Published Online：20 June 2022，
  
  Received：02 April 2022，
- 稿件说明：
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尹玉洁,常丽萍,朱垚等.基于脉络学说指导和医案数据挖掘的心血管事件链证治规律分析[J].中国实验方剂学杂志,2022,28(18):144-151.

YIN Yujie,CHANG Liping,ZHU Yao,et al.Vessel-collateral Theory Guided Rules of Syndrome and Treatment of Cardiovascular Event Chain Based on Medical Record Data Mining and Analysis[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(18):144-151.
尹玉洁,常丽萍,朱垚等.基于脉络学说指导和医案数据挖掘的心血管事件链证治规律分析[J].中国实验方剂学杂志,2022,28(18):144-151. DOI： 10.13422/j.cnki.syfjx.20220651.

YIN Yujie,CHANG Liping,ZHU Yao,et al.Vessel-collateral Theory Guided Rules of Syndrome and Treatment of Cardiovascular Event Chain Based on Medical Record Data Mining and Analysis[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(18):144-151. DOI： 10.13422/j.cnki.syfjx.20220651.

摘要

目的

以脉络学说为指导，基于医案数据挖掘分析结果探讨心血管事件链证治规律。

方法

采用多源数据库类研究，系统检索PubMed、中国知识基础设施工程（CNKI）、万方数据知识服务平台（Wanfang Data）、维普网（VIP）、中国生物医学文献服务系统（SinoMed）中代谢综合征、冠心病心绞痛、心肌梗死介入后、心肌梗死后心律失常及心肌梗死后心力衰竭相关医案，检索时限设置为数据库建库至2022年1月。提取医案中患者姓名、年龄、性别、症状、舌象、脉象、药物、病位等字段，基于脉络学说指导进行药物功效分类及证候分类判定，运用频数解构、系统聚类分析、FP-Growth关联分析等数据挖掘方法分析心血管事件链证治规律。

结果

心血管事件链上述5个关键病理环节中均出现营卫失常相关的证候表现；营卫“由络以通，交会生化”异常所继发的湿、痰、瘀、水在上述5个关键病理环节所占比重有所差异，相应用药组合所占频次也不相同。

结论

营卫失常为心血管事件链发病的始动因素并贯穿全过程，脉络末端营卫“由络以通、交会生化”异常可导致气血津液精输布代谢障碍，津聚为湿，湿凝为痰，血滞为瘀，瘀血化水，成为促进心血管事件链发展加重的内在驱动因素，导致“凝-壅-塞-不通”传变规律，构成了心血管事件链5个关键病理环节发展演变的核心病机。

Abstract

Objective

To explore the rules of syndrome and treatment of cardiovascular event chain based on the results of data mining of medical records under the guidance of vessel-collateral theory.

Method

Multi-source database research method was used to retrieve the medical records related to metabolic syndrome， angina pectoris of coronary heart disease， post-intervention of myocardial infarction， arrhythmia after myocardial infarction and heart failure after myocardial infarction between database inception and January 2022 from PubMed， China National Knowledge Infrastructure （CNKI）， Wanfang Data Knowledge Service Platform （Wanfang Data）， VIP and China Biomedical Literature Service System （SinoMed）. The fields of name， age， gender， symptoms， tongue image， pulse image， drug and disease location were extracted from these medical records， and drug efficacy classification and syndrome classification were determined based on vessel-collateral theory. The rules of syndrome and treatment of cardiovascular event chain were analyzed by data mining methods such as frequency deconstruction， systematic cluster analysis and FP-Growth association analysis.

Result

The above five key pathological links in the chain of cardiovascular event chain all showed symptoms related to the disorder of Yingwei. The proportion of dampness， phlegm， blood stasis and water secondary to the disorder of Yingwei in the above five key pathological links was different， and the frequency of corresponding drug combinations was also different.

Conclusion

The disorder of Yingwei is the initiating factor of cardiovascular event chain and runs through the whole process. The abnormality of Yingwei at the terminal of vessel-collateral may lead to the disorder of Qi， blood， body fluid and essence transportation and metabolism. Body fluid accumulates into dampness， dampness accumulates into phlegm， blood stagnation accumulates into blood stasis， blood stasis accumulates into water， which becomes an internal driving factor to promote the development and aggravation of cardiovascular event chain. It leads to the transmission law of Ning-Yong-Sai-Butong， which constitutes the core pathogenesis of the development and evolution of the five key pathological links of cardiovascular event chain.

关键词

脉络学说营卫理论心血管事件链证治规律FP-Growth关联分析频数解构聚类分析

Keywords

vessel-collateral theoryYingwei theorycardiovascular event chainrules of syndrome and treatmentFP-Growth correlation analysisfrequency deconstructioncluster analysis

references

DZAU V，BRAUNWALD E.Resolved and unresolved issues in the prevention and treatment of coronary artery disease：A workshop consensus statement［J］.Am Heart J，1991，121（4Pt1）：1244-1263.

YANG Y J，ZHAO J L，YOU S J，et al.Different effects of tirofiban and aspirin plus clopidogrel on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion［J］.Heart，2006，92（8）：1131-1137.

NICCOLI G，KHARBANDA R K，CREA F，et al.No-reflow：Again prevention is better than treatment［J］.Eur Heart J，2010，31（20）：2449-2455.

魏聪，贾振华，常丽萍.中医络病学科研究回顾与展望［J］.中医杂志，2015，56（22）：1971-1975.

胡嘉元.病机主导的中医临床个体化诊疗模式及决策支持系统构建［D］.北京：北京中医药大学，2020.

中华医学会糖尿病学分会.中国2型糖尿病防治指南（2013年版）［J］.中华糖尿病杂志，2014，22（8）：2-42.

梁峰，胡大一，方全，等.心肌梗死定义的全球统一和更新完善［J］.中国循证心血管医学杂志，2018，10（9）：1025-1030，1047.

曹克将，陈柯萍，陈明龙，等.2020室性心律失常中国专家共识（2016共识升级版）［J］.中国心脏起搏与心电生理杂志，2020，34（3）：189-253.

中国医师协会心血管内科医师分会，中国心血管健康联盟，心肌梗死后心力衰竭防治专家共识工作组.2020心肌梗死后心力衰竭防治专家共识［J］.中国循环杂志，2020，35（12）：1166-1180.

王一战.痢疾相关明清文献中医诊治经验挖掘研究［D］.北京：中国中医科学院，2017.

吴以岭，赵珊珊，魏聪，等.“脉络-血管系统病”调和营卫气血用药规律及常用通络药物［J］.疑难病杂志2018，17（3）：282-285，289.

李红蓉，贾振华，魏聪，等.脉络学说指导调和营卫气血治疗脉络病变方药数据挖掘及用药规律分析［J］.疑难病杂志，2019，18（1）：80-85.

贾振华，吴以岭，高怀林，等.“脉络-血管系统病”辨证诊断标准［J］.中医杂志，2007，48（11）：1027-1032.

吴以岭.脉络论［M］.北京：中国科学技术出版社，2010：11.

周仲瑛.中医内科学［M］.北京：中国中医药出版社，2004.

郭振球.实用中医诊断学［M］.上海：上海科学技术出版社，2013.

国家药典委员会.中华人民共和国药典：一部［M］.北京：中国医药科技出版社，2015.

钟赣生.中药学［M］.9版.北京：中国中医药出版社，2012.

刘兴方，韩学杰.数据挖掘技术在医案研究中的应用与讨论［J］.中国实验方剂学杂志， 2014，20（9）：247-250.

吴以岭，贾振华，常丽萍，等.脉络学说营卫理论指导血管病变防治研究［J］.中国实验方剂学杂志，2019，25（1）：1-10.

石梅，李霞.胰岛素抵抗及代谢综合征与1型糖尿病的研究进展［J］.中华糖尿病杂志，2021，13（6）： 637-639.

SHIOI A，IKARI Y.Plaque calcification during atherosclerosis progression and regression［J］.J Atheroscler Thromb，2018，25（4）：294-303.

彭瑞，王芳，丛祥凤，等.侵蚀斑块表面内皮细胞损伤的机制及其病理意义［J］.中国循环杂志，2018，33（S1）：11.

郑一，郭鹤，包永睿，等.基于NF-κB/NLRP3/Caspase-1通路介导的巨噬细胞焦亡探究葛根芩连汤对动脉粥样硬化易损斑块的干预机制［J］.中国实验方剂学杂志，2022，28（11）：70-78.

徐勤磊，丁勇，周国琪，等.从上焦“阳微阴弦”探讨寒凝心脉型冠心病防治［J］.中国中医基础医学杂志，2021，27（12）：1957-1959，1966.

张仲景.金匮要略［M］.2版.北京：中国中医药出版社，2007：110.

陈可冀.血瘀证与活血化瘀治疗的研究［J］.中国中医药现代远程教育，2005，3（11）：10-12.

吴以岭.中医络病学说与心脑血管病［M］.北京：中国科学技术出版社，2001.

于冬冬，李为民.ST段抬高型心肌梗死患者PCI术中无复流现象研究的进展［J］.心血管康复医学杂志，2021，30（6）：717-721.

郑士航，高曼，张飞飞，等.GRACE评分联合中性粒细胞与淋巴细胞比值对急性STEMI患者PCI后无复流现象的预测价值［J］.临床心血管病杂志，2021，37（9）：810-815.

郭慧慧，郭文玲.急性心肌梗死后冠状动脉微循环障碍认识进展［J］.中西医结合心脑血管病杂志，2021，19（14）：2356-2360.

王康，常丽萍，尹玉洁，等.基于脉络学说指导的急性心肌梗死后心肌纤维化中医病机及临床治疗探讨［J］.中国实验方剂学杂志，2021，27（12）：189-195.

ZEISBERG E M，TARNAVSKI O，ZEISBERG M，et al.Endothelial-to-mesenchymal transition contributes to cardiac fibrosis［J］.Nat Med，2007，13（8）：952-961.

WIDYANTORO B，EMOTO N，NAKAYAMA K，et al.Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition［J］.Circulation，2010，121（22）：2407- 2418.

EVRARD S M，LECCE L，MICHELIS K C，et al.Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability［J］.Nat Commun，2016，7：11853.

PIERA-VELAZQUEZ S，JIMENEZ S A.Endothelial to mesenchymal transition：Role in physiology and in the pathogenesis of human diseases［J］.Physiol Rev，2019，99（2）：1281-1324.

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