Regulatory Effect of Qingfei Xiegan Tang on Inflammatory Response and Intestinal Flora of Type 2 Diabetes Mellitus

Cong-shu DAI; Zhuo YU; Guang-yao LI; Chang-qing LIN

doi:10.13422/j.cnki.syfjx.20191327

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Regulatory Effect of Qingfei Xiegan Tang on Inflammatory Response and Intestinal Flora of Type 2 Diabetes Mellitus

Clinic | 更新时间：2021-02-09

- Regulatory Effect of Qingfei Xiegan Tang on Inflammatory Response and Intestinal Flora of Type 2 Diabetes Mellitus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 18, Pages: 83-88(2019)
- 作者机构：
  
  延边大学　医学院，吉林　延吉　 133000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191327
  CLC： R22; R242; R2-031; R287
- Published：20 September 2019，
  
  Published Online：20 March 2019，
  
  Received：03 January 2019，
- 稿件说明：
扫描看全文
Cong-shu DAI, Zhuo YU, Guang-yao LI, et al. Regulatory Effect of Qingfei Xiegan Tang on Inflammatory Response and Intestinal Flora of Type 2 Diabetes Mellitus. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):83-88(2019)
DOI：

Cong-shu DAI, Zhuo YU, Guang-yao LI, et al. Regulatory Effect of Qingfei Xiegan Tang on Inflammatory Response and Intestinal Flora of Type 2 Diabetes Mellitus. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(18):83-88(2019) DOI： 10.13422/j.cnki.syfjx.20191327.

摘要

目的：

观察清肺泻肝汤治疗太阴人2型糖尿病(T2DM)的疗效及对炎症指标和肠道菌群的调节作用。

方法：

将122例患者随机分为对照组(65例)和观察组(67例)。对照组给予盐酸二甲双胍片，0.25 g/次，2～3次/d，根据血糖控制情况调整剂量。观察组在对照组的基础上给予清肺泻肝汤加减治疗，1剂/d。疗程2个月。检测治疗前后空腹血糖(FPG)，餐后2 h血糖(2 h PG)，糖化血红蛋白(HbA1c)和空腹胰岛素(FINS)，并计算胰岛素敏感指数(ISI)和胰岛素抵抗指数(HOMA-IR)；检测治疗前后三酰甘油(TG)，总胆固醇(TC)，高密度脂蛋白胆固醇(HLD)和低密度脂蛋白(LDL-C)水平；检测治疗前后白细胞介素-6(IL-6)，IL-8，肿瘤坏死因子-

(TNF-

)和C反应蛋白(CRP)水平；进行治疗前后肠道菌群检测和治疗前后朝鲜族医学证候评分。

结果：

经秩和检验，观察组疾病疗效优于对照组(

0.01)；治疗后观察组血清FPG，2 h PG，HbA1c，FINS水平低于对照组(

0.01)，HOMA-IR低于对照组(

0.01)，ISI高于对照组(

0.01)；观察组患者血浆TC，TG和LDL-C水平较对照组降低(

0.01)，HDL-C较对照组升高(

0.01)；观察组血清IL-6，IL-8，TNF-

和CRP水平低于对照组(

0.01)；观察组肠道需氧菌群(肠杆菌、肠球菌、酵母菌)数量低于对照组(

0.05)，肠道厌氧菌群(拟杆菌、双歧杆菌、乳杆菌)数量高于对照组(

0.05)。

结论：

清肺泻肝汤可进一步改善太阴人T2DM患者胰岛素抵抗(IR)，调节血糖和血脂水平，减轻临床症状，抑制炎症反应，调节肠道菌群，临床疗效优于单纯的西医治疗。

Abstract

Objective:

To observe the clinical efficacy of Chaoyi Qingfei Xiegan Tang on type 2 diabetes mellitus (T2DM)

and the regulatory effect on inflammatory markers and intestinal flora.

Method:

One hundred and twenty-two patients were randomly divided into control group (65 cases) and observation group (67 cases) by random number table. Patients in control group got metformin hydrochloride

0.25 g/time

2-3 times/day

and the dose was regulated based on glycemic control. In addition to the therapy in control groups

patients in observation group were also given Qingfei Xiegan Tang

1 dose/day. A course of treatment was 2 months. Before and after treatment

levels of fasting blood glucose (FPG)

2 h-postprandial plasma glucose (2 h PPG)

glycosylated hemoglobin (HbA1c)

fasting insulin (FINS)

triglyceride (TG)

total cholesterol (TC)

high-density lipoprotein cholesterol (HLD)

low-density lipoprotein (LDL-C)

interleukin-6 (IL-6)

IL-8

tumor necrosis factor-

(TNF-

) and C-reactive protein (CRP) were detected. And insulin sensitivity index (ISI)

HOMA insulin resistance index (HOMA-IR) and intestinal flora were detected. And scores of TCM symptoms were graded.

Result:

By rank sum test

the clinical efficacy of disease in observation group was better than that in control group (

0.01). After treatment

levels of FPG

2 h PG

HbA1c

FINS

HOMA-IR

LDL-C

IL-6

IL-8

TNF-

and CRP were lower than those in control group (

0.01)

and levels of ISI

HDL-C were higher than those in control group (

0.01). And the number of intestinal aerobic bacteria (enterobacter

enterococcus and yeast) was less than that in control group (

0.05)

and intestinal anaerobic flora (bacteroides

bifidobacterium and lactobacillus) were higher than those in control group (

0.05).

Conclusion:

Qingfei Xiegan Tang can ameliorate 2 h PG

regulate levels of glucose

lipid and intestinal flora

relieve clinical symptoms

and inhibit inflammatory response

with a better clinical efficacy than that of pure western medicine.

关键词

2型糖尿病太阴人清肺泻肝汤炎症反应肠道菌群

Keywords

type 2 diabetes mellitusTaiyinrenQingfei Xiegan Tanginflammatory responseintestinal flora

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