Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF<italic style="font-style: italic">-α</italic>, IL-8, IL-6, IL-1<italic style="font-style: italic">β</italic> and Cys-C in Patients at Stable Stage of COPD

Ming-ru HUANG; Zhong-bo XU; Fan HE; Tian-fu OUYANG; Ming-liang XU

doi:10.13422/j.cnki.syfjx.20191625

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Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF-α, IL-8, IL-6, IL-1β and Cys-C in Patients at Stable Stage of COPD

Clinic | 更新时间：2021-02-09

- Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF-α, IL-8, IL-6, IL-1β and Cys-C in Patients at Stable Stage of COPD
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 22, Pages: 60-65(2019)
- 作者机构：
  
  1.江西中医药大学，南昌　 330004；
  2.江西中医药大学　附属医院，南昌　 330006；
  3.广州中医药大学　基础医学院，广州　 510006；
  4.厦门大学　化学化工学院，厦门　 361005
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191625
  CLC： R22; R242; R2-031; R287
- Published：20 November 2019，
  
  Published Online：07 May 2019，
  
  Received：09 December 2018，
- 稿件说明：
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Ming-ru HUANG, Zhong-bo XU, Fan HE, et al. Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF-α, IL-8, IL-6, IL-1β and Cys-C in Patients at Stable Stage of COPD. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):60-65(2019)
DOI：

Ming-ru HUANG, Zhong-bo XU, Fan HE, et al. Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF-α, IL-8, IL-6, IL-1β and Cys-C in Patients at Stable Stage of COPD. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):60-65(2019) DOI： 10.13422/j.cnki.syfjx.20191625.

摘要

目的：

观察补中益气汤加味联合缩唇呼吸疗法(pursed-lips breathing，PLB)对稳定期肺脾气虚兼血瘀型慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)患者血清肿瘤坏死因子-

(tumornecrosis factor-

，TNF-

)，白细胞介素-8(interleukin-8，IL-8)，IL-6，IL-1

，血清胱抑素-C(Serum cystatin C，Cys-C)的影响。

方法：

2017年9月至2018年3月于江西中医药大学附属医院肺病科就诊的120例符合纳入标准的门诊或住院部COPD患者，采用随机数字表随机分为治疗组和对照组，对照组(60例)予噻托溴铵粉雾剂治疗(18 μg/次，1次/d)，治疗组(60例)在前者基础之上予以补中益气汤加味联合PLB疗法，两组均为期6个月的治疗。6个月后观察两组患者治疗前后患者临床有效率，第1秒用力呼气容积占预计值百分比(FEV

%)，第1秒用力呼气容积占用力肺活量的百分比(FEV

/FVC)，6 min步行距离(six-minute walk distance，6MWD)，测定血液中TNF-

，IL-8，IL-6，IL-1

及Cys-C水平。

结果：

6个月后治疗组的临床有效率为93.33%，对照组的临床有效率为86.67%，治疗组临床有效率高于对照组(

0.05)。与本组治疗前比较，两组治疗后FEV

%，FEV

/FVC，6MWD均增加(

0.05)；与对照组治疗后比较，治疗组FEV

%，FEV

/FVC及6MWD均增加(

0.05)。与本组治疗前比较，两组治疗后血清TNF-

，IL-8，IL-6，IL-1

，Cys-C水平均减少(

0.05)；与对照组治疗后比较，治疗组TNF-

，IL-8，IL-6，IL-1

，Cys-C水平均减少(

0.05)。

结论：

补中益气汤加味联合PLB疗法通过减少COPD患者气道中炎症细胞因子TNF-

，IL-8，IL-6，IL-1

水平，降低COPD慢性炎症的标记物Cys-C的水平，减少炎症反应发生，改善气流阻塞状况，提升COPD患者FEV

%，FEV

/FVC水平，从而达到改善COPD患者肺功能及生活质量的目的。

Abstract

Objective:

To observe the effect and mechanism of modified Buzhong Yiqi Tang and pursed-lips breathing (PLB) on serum tumor necrosis factor-alpha (TNF-

)

interleukin-8 (IL-8)

IL-6

IL-1

and serum cystatin C (Cys-C) in patients of chronic obstructive pulmonary disease (COPD) at the stable stage.

Method:

Totally 120 cases of COPD treated at Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from September 2017 to March 2018 conformed to the inclusion criteria

and were randomly divided into treatment group (60 cases) and control group (60 cases). Cases of control group received Tiotropium (18 μg/ time

). In addition to the therapy of control group

cases of treatment group were also given Buzhong Yiqi Tang and PLB. Both groups were treated for 6 months. Percent of forced expiratory volume in one second in predicted value (FEV

ratio of FEV

to forced vital capacity (FEV

/FVC)

six-minute walk distance (6MWD)

TNF-

IL-8

IL-6

IL-1

and Cys-C were compared between both groups.

Result:

After treatment

the clinical efficacy rate of observation group was 93.33%

which was evidently higher than 86.67%of control group (

0.05). Compared with before treatment

both groups showed decreases in TNF-

IL-8

IL-6

IL-1

Cys-C but increases in FEV

FEV

/FVC (

0.05). Compared with control group

treatment group showed decreases in TNF-

IL-8

IL-6

IL-1

Cys-C but increases in FEV

FEV

/FVC (

0.05).

Conclusion:

Buzhong Yiqi Tang and PLB has an anti-inflammatory effect on COPD by reducing levels of inflammation cytokines TNF-

IL-8

IL-6

IL-1

and chronic inflammation markers serum Cys-C and inflammatory reaction

and alleviating airflow obstruction

promoting the levels of FEV

FEV

/FVC

pulmonary function control inflammatory factors

so as to improve pulmonary function and the quality of life in patients with COPD.

关键词

慢性阻塞性肺疾病稳定期补中益气汤缩唇呼吸疗法炎症细胞因子血清胱抑素C

Keywords

chronic obstructive pulmonary disease(COPD)stable periodBuzhong Yiqi Tangpursed-lips Breathing (PLB)inflammatory cytokinesserum cystatin-C(Cys-C)

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Related Author

Wei-min LIAO

Zhong-bo XU

Ming-ru HUANG

Su-you ZHU

YUAN Shasha

SHI Xia

WANG Bing

MIAO Qing

Related Institution

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (TCM)

Jiangxi University of TCM

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Faculty of Environment and Life，Beijing University of Technology

Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

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⁰

Effect and Mechanism of Modified Buzhong Yiqi Tang and Pursed-lips Breathing on Serum TNF-α, IL-8, IL-6, IL-1β and Cys-C in Patients at Stable Stage of COPD

DOI：10.13422/j.cnki.syfjx.20191625

摘要

Abstract

关键词

Keywords

references