Establishment of Determination of Fractal Dimension of Ethanol-precipitated Flocs of Two Root Medicinal Herbs

Feng SHAO; Meng-ying YU; Mei-lin JIANG; Ming YANG; Yue SHANG; Rong-hua LIU; Xue-yu ZHANG

doi:10.13422/j.cnki.syfjx.20191454

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Establishment of Determination of Fractal Dimension of Ethanol-precipitated Flocs of Two Root Medicinal Herbs

Pharmacy and Processing | 更新时间：2021-02-09

- Establishment of Determination of Fractal Dimension of Ethanol-precipitated Flocs of Two Root Medicinal Herbs
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 22, Pages: 103-107(2019)
- 作者机构：
  
  1.江西中医药大学　现代中药制剂教育部重点实验室，南昌　 330004；
  2.国家药典委员会，北京　 100061
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191454
  CLC： R22; O6; R28; C37; Q246
- Published：20 November 2019，
  
  Published Online：03 April 2019，
  
  Received：21 January 2019，
- 稿件说明：
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Feng SHAO, Meng-ying YU, Mei-lin JIANG, et al. Establishment of Determination of Fractal Dimension of Ethanol-precipitated Flocs of Two Root Medicinal Herbs. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):103-107(2019)
DOI：

Feng SHAO, Meng-ying YU, Mei-lin JIANG, et al. Establishment of Determination of Fractal Dimension of Ethanol-precipitated Flocs of Two Root Medicinal Herbs. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):103-107(2019) DOI： 10.13422/j.cnki.syfjx.20191454.

摘要

目的：

建立黄芪与板蓝根2种根类药材醇沉絮体的分形维数测定方法。

方法：

分别以黄芪、板蓝根的水提醇沉絮体为研究对象，采用大津算法对醇沉絮体原始显微图像进行二值化处理，运用周长-面积法分别考察沉淀絮体取样体积、稀释倍数、图像放大倍数及图像采集位点数对分形维数的影响。

结果：

黄芪与板蓝根醇沉絮体均具有分形特征；确定这2个醇沉絮体取样体积在600～800 μL，样品稀释至5～20倍，显微图像放大200倍或400倍，选取4个图像采集位点时，能够得到稳定可靠的醇沉絮体分形维数。

结论：

建立的测定方法稳定可行，可为根类药材醇沉絮体的分形理论研究提供参考。

Abstract

Objective:

To establish a method for the determination of fractal dimension of ethanol precipitation flocs in two kinds of root medicinal herbs (Astragali Radix and Isatidis Radix).

Method:

The ethanol-precipitated flocs of Astragali Radix and Isatidis Radix were taken as the research objects. Firstly

the original microscopic images of the ethanol precipitation flocs were binarized by Ostu algorithm. Secondly

the influence of sampling volume

dilution multiple

image magnification ratio and number of image acquisition sites on fractal dimension was investigated using perimeter-area method.

Result:

The ethanol precipitation flocs of Astragali Radix and Isatidis Radix had fractal characteristics. At the same time

the stable and reliable fractal dimension of the flocs could be obtained when the sampling volume was 600-800 μL

the sample was diluted to 5-20 times

the microscopic image was enlarged to 200 times or 400 times

and four different image acquisition sites were selected.

Conclusion:

The established method is stable and feasible

which can provide reference for the fractal theory of ethanol precipitation flocs of root medicinal herbs.

关键词

分形维数醇沉絮体黄芪板蓝根显微图像颗粒剂

Keywords

fractal dimensionethanol precipitationflocsAstragali RadixIsatidis Radixmicroscopic imagesgranules

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