Chemical Constituents in Endophytic Fungus <italic style="font-style: italic">Nigrospora oryzae</italic> from Cordyceps

Xiao-hua LI; Yu-mei CAO; Meng-ying JIN; Lei-qiang GONG; Da-le GUO; Yun DENG

doi:10.13422/j.cnki.syfjx.20191514

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Chemical Constituents in Endophytic Fungus Nigrospora oryzae from Cordyceps

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- Chemical Constituents in Endophytic Fungus Nigrospora oryzae from Cordyceps
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 22, Pages: 126-131(2019)
- 作者机构：
  
  成都中医药大学　药学院　中药材标准化教育部重点实验室，四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地，成都　 611137
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191514
  CLC： R284.2; R289; R22
- Published：20 November 2019，
  
  Published Online：19 April 2019，
  
  Received：27 October 2018，
- 稿件说明：
扫描看全文
Xiao-hua LI, Yu-mei CAO, Meng-ying JIN, et al. Chemical Constituents in Endophytic Fungus Nigrospora oryzae from Cordyceps. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):126-131(2019)
DOI：

Xiao-hua LI, Yu-mei CAO, Meng-ying JIN, et al. Chemical Constituents in Endophytic Fungus Nigrospora oryzae from Cordyceps. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):126-131(2019) DOI： 10.13422/j.cnki.syfjx.20191514.

摘要

目的：

研究冬虫夏草内生菌

Nigrospora oryzae

的化学成分。

方法：

采用糙米对其进行扩大培养，利用柱色谱、制备色谱等手段进行分离纯化，并利用核磁共振(NMR)，电喷雾质谱(ESI-MS)等手段对化合物进行结构鉴定。

结果：

分离得到15个化合物，分别为蜂蜜曲菌素(mellein，1)，亚油酸(linoleic acid，2)，2-(2-羟乙基)苯酚[2-(2-hydroxyethyl)phenol，3]，(3

)-甲基亮氨酸甲酯[(3

)-mellein methyl ether，4]，(3

，4

)-4-hydroxymellein(5)，2-羟基苯甲醛(2-hydroxybenzaldehyde，6)，3-苯丙-1，2-二醇(3-phenylpropane-1，2-diol，7)，苯乙二醇(1-phenyl-1，2-ethanediol，8)，恩镰包菌素B(enniatin B，9)，(22

，24

)-麦角甾-7，22-二烯-3

，5

，9

-三醇-6-酮[(22

，24

)-ergost-7，22-dien-3

，5

，9

-riol-6-one，10]，环-(

-脯氨酸-

-缬氨酸)[

cyclo

-Pro-

-Val)，11]，4-hydroxy-8-

-methylmellein(12)，环-(

-脯氨酸-

-苯丙氨酸)[

cyclo

-Pro-

-Phe)，13]，环-(

-脯氨酸-

-异亮氨酸)[

cyclo

-Pro-

-Ile)，14]，环-(

-脯氨酸-

-亮氨酸)[

cyclo

-Pro-

-Leu)，15]。

结论：

化合物

1～15

为首次从该真菌中分离得到。

Abstract

Objective:

To study the chemical constituents in theendophytic fungus

Nigrospora oryzae

from Cordyceps.

Method:

It was cultured with brownrice

and isolated and purified by chromatographic procedures

and the compounds were identified by NMR

ESI-MS and other spectral methods.

Result:

Totally 15 compounds were identified as mellein (1)

linoleic acid (2)

2-(2-hydroxyethyl)phenol (3)

)-mellein methyl ether (4)

)-4-hydroxymellein (5)

2-hydroxybenzaldehyde (6)

3-phenylpropane-1

2-diol (7)

1-phenyl-1

2-ethanediol (8)

cyclo

-Prommmm-

-Ile) (9)

cyclo

-Pro-

-Leu) (10)

2-hydroxybenzaldehyde (11)

4-hydroxy-8-

-methylmellein (12)

cyclo

-Pro-

-Phe) (13)

cyclo

-Pro-

-Ile) (14)

cyclo

-Pro-

-Leu) (15).

Conclusion:

Compounds 1-15were isolated from this fungus for the first time.

关键词

冬虫夏草Nigrospora oryzae内生菌蜂蜜曲菌素

Keywords

CordycepsNigrospora oryzaeendophytic fungusmellein

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Chemical Constituents in Endophytic Fungus Nigrospora oryzae from Cordyceps

DOI：10.13422/j.cnki.syfjx.20191514

摘要

Abstract

关键词

Keywords

references