Objective: To mine the clinical medication experience of marine Chinese medicine Sepiae Endoconcha accumulated during the development

in order to build the clinical medication experience mode of Sepiae Endoconcha

and provide the data support for the clinical application and further research of Sepiae Endoconcha. Method: Dictionary of Tradition Chinese Medicine Prescriptions and Encyclopedia of Traditional Chinese Medicine was chosen as basic information sources of formulas. Formulas containing Sepiae Endoconcha were screened

and their information was standardized. Frequency analysis

association rules mining technique and association network building technique were applied to analyze the selected formulas. Result: Totally 721 formulas were screened according to the criteria

involving 662 kinds of Chinese herbal medicines. The most frequently combined medicines with Sepiae Endoconcha were Os Draconis

Angelicae Sinensis Radix and Halloysitum Rubrum. Cuttlebone was usually combined with Trionycis Carapax and Aconiti Lateralis Radix Proeparata to treat malaria

with Angelicae Sinensis Radix to treat leucorrhea

and with Typhae Pollen to treat uterine bleeding. According to the association network

gynecological and ear

nose

throat(ENT) diseases

such as leucorrhea

pollen typhae and otitis media suppurativa

had very high clusters. According to the network relation map for the node of interstitial keratitis

Sepiae Endoconcha could be combined with camphol and white lilac to treat interstitial keratitis in the dosage form of ointment for external use. Conclusion: According to medication experience in Sepiae Endoconcha's main efficacies

clinical dosage and usage

and compatibility regularity accumulated by physicians of previous dynasties

this thesis is conducive to supplementing the knowledge of marine Chinese medicine Sepiae Endoconcha

and providing the reference and foundation for the modern clinical application and new drug development of Sepiae Endoconcha