纸质出版:2018
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明惠仪, 麻秀萍, 杨菁, 等. 民族药地稔研究的现状分析[J]. 中国实验方剂学杂志, 2018,24(11):228-234.
MING Hui-yi, MA Xiu-ping, YANG Jing, et al. Research Status of [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(11): 228-234.
明惠仪, 麻秀萍, 杨菁, 等. 民族药地稔研究的现状分析[J]. 中国实验方剂学杂志, 2018,24(11):228-234. DOI: 10.13422/j.cnki.syfjx.20181019.
MING Hui-yi, MA Xiu-ping, YANG Jing, et al. Research Status of [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(11): 228-234. DOI: 10.13422/j.cnki.syfjx.20181019.
目的:整理及分析民族药地稔的研究文献,概述其论文分布、化学成分、药理活性、质量控制、临床应用与专利获批状况,为地稔的临床应用和进一步的开发利用提供参考依据及文献资料。方法:以"中国知网"与"Pubmed"作检索平台,"关键词"、"摘要"为检索项,分别以"地稔","地菍","嘎狗噜","Melastoma dodecandrum Lour."和"Melastoma dodecandrum"作检索词,检索地稔1973-2017年间国内外的论文报道与专利获批情况。结果:共得论文119篇,专利139项,论文内容以农林栽培、化学成分、质量控制和药理活性研究为主,专利以复方居多。目前从地稔中分离鉴定了83个化学成分,其中以黄酮类为主。质量控制指标多为没食子酸、槲皮素等成分,药理活性以降血糖作用研究居多。结论:地稔的止血作用显著,资源丰富,极具市场竞争力,但地方标准检查项不全,含量测定缺乏专属性指标评价药材优劣,需深入探索地稔止血的作用机制,研究其活性物质基础,建立谱效关系,从而控制地稔药材质量,利于天然药物资源的利用与开发。
Objective: To collect and analyze the reported literature of Melastoma dodecandrum
summarize the paper distribution
chemical compositions
pharmacological activity
quality control
clinical application and patent application status
and provide reference and literature for its clinical application and further development. Method: With “CNKI” and “Pubmed” as the search platform
“key words” and “abstract” as search terms
“diren”
“gagoulu”
“Melastoma dodecandrum Lour.” and “M. dodecandrum” as search words
the papers and patents of M. dodecandrum at home and abroad from 1973 to 2017 were retrieved in this study. Result: 119 papers and 139 patents were obtained
mainly about agriculture and forestry cultivation
chemical composition
quality control and pharmacological activity research in papers
and mainly about compound products in patents. At present
83 chemical constituents were isolated and identified from M. dodecandrum
mainly including flavonoids. Quality control indicators mainly included gallic acid
quercetin and so on
and the pharmacological research was mainly on hypoglycemic effect. Conclusion: M. dodecandrum had significant hemostatic effects with rich resource and high market competitiveness. However
the local standards were not complete
lacking specific indicators to evaluate the quality of medicinal herbs. Therefore
it is necessary to explore the mechanism of hemostasis in depth
study the basis of its active substances
and establish the relationship between spectrum efficiency and efficacy so as to control the quality of medicinal herbs
and promote the utilization and development of natural medicine resources.
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