地贞颗粒对围绝经期综合征患者阴虚内热证神经-内分泌的影响

马璇; 蒋丽; 杨燕芬; 胡秀英

doi:10.13422/j.cnki.syfjx.20181218

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地贞颗粒对围绝经期综合征患者阴虚内热证神经-内分泌的影响

临床 | 更新时间：2024-01-04

- 地贞颗粒对围绝经期综合征患者阴虚内热证神经-内分泌的影响
- Effect of Dizhen Grain on Neuro-endocrine of Menopausal Syndrome with Internal Heat Due to Yin Deficiency
- 中国实验方剂学杂志 2018年24卷第12期页码：182-187
- 作者机构：
- 作者简介：
- 基金信息：
  
  贵州省科技计划项目（黔科合LH学20147130）;六盘水市科技计划项目（52020-2013-1-003）
- DOI：10.13422/j.cnki.syfjx.20181218
  中图分类号： R271.116
- 纸质出版：2018
- 稿件说明：
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马璇, 蒋丽, 杨燕芬, 等. 地贞颗粒对围绝经期综合征患者阴虚内热证神经-内分泌的影响[J]. 中国实验方剂学杂志, 2018,24(12):182-187.

MA Xuan, JIANG Li, YANG Yan-fen, et al. Effect of Dizhen Grain on Neuro-endocrine of Menopausal Syndrome with Internal Heat Due to Yin Deficiency[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(12): 182-187.
马璇, 蒋丽, 杨燕芬, 等. 地贞颗粒对围绝经期综合征患者阴虚内热证神经-内分泌的影响[J]. 中国实验方剂学杂志, 2018,24(12):182-187. DOI： 10.13422/j.cnki.syfjx.20181218.

MA Xuan, JIANG Li, YANG Yan-fen, et al. Effect of Dizhen Grain on Neuro-endocrine of Menopausal Syndrome with Internal Heat Due to Yin Deficiency[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(12): 182-187. DOI： 10.13422/j.cnki.syfjx.20181218.

摘要

目的：观察地贞颗粒对阴虚内热型围绝经期综合征（MPS）患者的疗效，探讨其对神经-内分泌的作用影响。方法：将收治的MPS 130例患者，按数字表法随机分为对照组和治疗组各65例。对照组口服谷维素片，2片/次，3次/d。治疗组在对照组治疗的基础上采取地贞颗粒治疗， 1袋/次，3次/d。两组患者均连续治疗3个月。比较两组患者Kupperman指数（KI）评分、围绝经期生存质量量表（MENQOL）评分及临床疗效。检测两组患者血清中白细胞介素（IL-6），5-羟色胺（HT），促肾上腺皮质激素释放激素（CRH），促肾上腺皮质激素（ACTH），皮质酮（CORT），促性腺激素释放激素（GnRH），去甲肾上腺素（NE）以及雌二醇（E2），卵泡刺激素（FSH）和黄体生成素（LH）水平。测定两组患者治疗前后血浆β-内啡肽（β-EP）水平。结果：治疗后，治疗组KI评分和MENQOL各指标评分均明显低于对照组（P<0.01）。治疗组患者临床疗效总有效率为98.46%，优于对照组总有效率87.69%（χ2=4.298，P<0.05）。治疗后，治疗组患者血清IL-6，CRH，ACTH，CORT，GnRH，NE水平均明显低于对照组，5-HT高于对照组（P<0.01）。治疗后，治疗组患者血浆β-EP水平显著高于对照组（P<0.01）。治疗后，治疗组血清E2水平显著高于对照组，FSH，LH水平均明显低于对照组（P<0.01）。结论：在常规西医治疗的基础上，加服地贞颗粒可以使MPS患者阴虚内热证疗效明显，其调节患者的神经-内分泌途径可能与其疗效有关。

Abstract

Objective: To observe the efficacy of Dizhen grain in treating menopausal syndrome (MPS) with internal heat due to yin deficiency

in order to investigate its effect on neuro-endocrine. Method: Totally 130 cases with MPS were selected and randomly divided into control group (65 cases) and treatment group (65 cases). Control group was orally treated with Oryzanol tablets

2 tablets/time

tid. In addition to the therapy of control group

treatment group was given Dizhen grain

1 bag/time

tid. Both groups were observed for 3 months. Scores of Kupperman (KI)

Menopause-specific quality of life (MENQOL) and efficacy were compared between the two groups. Serum levels of interleukin (IL)-6

5-hydroxytryptamine (HT)

corticosteroid releasing hormone (CRH)

corticosteroid (ACTH)

corticosterone (CORT)

gonadotropin releasing hormone (GnRH)

norepinephrine (NE) and serum estradiol (E2)

follicle-stimulating hormone (FSH)

luteinizing hormone (LH) were detected in both groups. Plasma level of β-endorphin (β-EP) was measured in the two groups. Result: After treatment

scores of KI and indexes of MENQOL of treatment group were obviously lower than those of control group (P<0.01). The total effective rate of treatment group was 98.46%

which was superior to 87.69%of control group (χ2=4.298

P<0.05). After treatment

serum levels of IL-6

CRH

ACTH

CORT

GnRH

NE of treatment group were remarkably lower than those of control group

while 5-HT was higher (P<0.01). Plasma level of β-EP of treatment group was evidently higher than that of control group (P<0.01). After treatment

serum level of E2 of treatment group was remarkably higher than control group

while FSH and LH were lower (P<0.01). Conclusion: In addition to the therapy of control group

Dizhen grain has a significant effect in treating MPS with syndrome of internal heat due to Yin deficiency

which may be related to the regulation of neuro-endocrine.

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