Objective: To discuss the efficacy of Shenfutang combined with Huanglian Ejiao Tang in improving the postoperative cognitive dysfunction (POCD) of patients with postoperative delirium (POD) after orthopedics operation

and its effect on levels of neuron specific enolase (NSE)

S-100β protein

inflammatory response and oxidative stress injury. Method: One hundred and four patients were randomly divided into control (52 cases) group and observation group (52 cases) according to the ratio of 1 to 1.Patients in control group got haloperidol tablets

4-20 mg/days

3 take. In addition to the therapy for control groups

patients in observation group were also given modified Shenfutang combined with Huanglian Ejiao Tang

1 dose/day

for 10 successive days. And the mini-mental state examination (MMSE)

delirium rating scale (DRS)

disappearance time of postoperative delirium and delirium rating scale (DRS-R-98) were evaluated. Before and after treatment

levels of NSE

S-100β

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

superoxide dismutase (SOD) and malondialdehyde (MDA) were detected. The clinical efficacy was evaluated by the scale of clinical global impression (CGI-GI). Result: The total effective rate in observation group was 88.64%

which was higher than 69.23%in control group (χ2=5.765

P<0.05). And at the 5th and 10th day after the treatment

scores of CAM and DRS-R-98 in observation group were lower than those in control group

and MMSE was higher than that in control group (P<0.05

P<0.01). CAM and DRS-R-98 in observation group reduced more significantly than those in control group

but MMSE increased more significantly than that in control group (P<0.01). Scores of ADL and traditional Chinese medicine(TCM) syndrome in observation group were both lower than those in control group (P<0.01). The average disappearance time of postoperative cognitive dysfunction in observation group was shorter than that in control group (P<0.01). And levels of NSE

S-100β

IL-6

TNF-α and MDA in observation group were lower than those in control group

while level of SOD was higher (P<0.01). Conclusion: Modified Shenfutang combined with Huanglian Ejiao Tang can promote the recovery of POD

improve the cognitive function

relieve symptoms

reduce oxidative stress and injury caused by inflammatory reaction

improve the daily living ability

and protect brain nerve cells

and thus is worth clinical application.