钩吻的化学成分及药理作用研究进展

赵雅婷; 武淑鹏; 胡春丽; 亢晶; 赵猛

doi:10.13422/j.cnki.syfjx.20182118

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钩吻的化学成分及药理作用研究进展

综述 | 更新时间：2021-02-09

- 钩吻的化学成分及药理作用研究进展
- Reviews on Chemical Compositions and Pharmacological Effect of Gelsemium elegans
- 中国实验方剂学杂志 2019年25卷第3期页码：200-210
- 作者机构：
  
  山西师范大学，山西　临汾　 041000
- 作者简介：
  
  赵雅婷，在读硕士，从事结构植物学研究工作，E-mail: zytsxsfdx2005@163.com
  *赵猛，博士，副教授，从事结构植物学研究工作，Tel: 0357-2051196，E-mail: zhaomeng@sxnu.edu.cn
- 基金信息：
  
  国家自然科学基金青年基金项目(31300157);山西师范大学研究生科技创新项目(011001053003)
- DOI：10.13422/j.cnki.syfjx.20182118
  中图分类号： R284.1;R285.5;R289;R22
- 收稿：2018-03-17，
  
  网络首发：2018-08-24，
  
  纸质出版：2019-02-05
- 稿件说明：
移动端阅览
赵雅婷, 武淑鹏, 胡春丽, 等. 钩吻的化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(3):200-210.

Ya-ting ZHAO, Shu-peng WU, Chun-li HU, et al. Reviews on Chemical Compositions and Pharmacological Effect of Gelsemium elegans[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(3): 200-210.
赵雅婷, 武淑鹏, 胡春丽, 等. 钩吻的化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(3):200-210. DOI： 10.13422/j.cnki.syfjx.20182118.

Ya-ting ZHAO, Shu-peng WU, Chun-li HU, et al. Reviews on Chemical Compositions and Pharmacological Effect of Gelsemium elegans[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(3): 200-210. DOI： 10.13422/j.cnki.syfjx.20182118.

摘要

钩吻

Gelsemium elegans

，马钱科Loganiaceae钩吻属

Gelsemium

常绿木质藤本植物，为中国传统药用植物，其味辛、苦，性温，有剧毒，常用来祛风、攻毒、消肿和止痛。该文检索并查阅了近些年来钩吻在化学成分和药理作用方面的文献，并对其进行总结和归纳。目前的研究表明，已从钩吻中分离出生物碱、环烯醚萜、三萜类、酚酸类、甾体类、香豆素、木脂素、四甲基环己烯型单萜苷类化合物、黄酮类等多种成分，其中，钩吻生物碱多为吲哚类生物碱，是其主要的活性成分，能显著抑制中枢神经活动。现代药理学研究表明钩吻生物碱具有多种药理活性，可通过调控细胞周期来达到抗肿瘤的目的；增强巨噬细胞吞噬能力，保护白细胞，促进机体免疫调节；治疗癌性疼痛和长期疼痛；使心肌收缩力减弱，血管舒张以达到降压效果；另外还对焦虑症和皮肤病的治疗起到一定作用。在今后的研究中，仍需对钩吻的化学成分进行深入研究，开发有前景的先导化合物，并进一步明确毒理和药理临床价值，探明作用机制，使其得到更充分合理的利用，为钩吻扩大应用和安全使用奠定基础。

Abstract

Gelsemium elegans

the evergreen woody vine of the genus

Gelsemium

of the Loganiaceae family in China

is a traditional Chinese medicinal plant. It is spicy

bitter

warm

highly toxic and commonly used for dispelling wind-evil

attacking poison

reducing swelling and relieving pain. In this article

the researches on the chemical constituents and pharmacological effects of

elegans

in recent years were retrieved

reviewed and summarized. So far

alkaloids

iridoids

triterpenes

phenolic acids

steroids

coumarins

lignans

megastigmane glycosides and other ingredients have been separated from

elegans

. Alkaloids

mostly of indole alkaloids

are the main active ingredients there of which can significantly inhibit central nervous activity. Modern pharmacological studies have shown that alkaloids have a variety of pharmacological activities

which can achieve the purpose of anti-tumor by regulating cell cycle; enhance macrophage phagocytosis

protect white blood cells

and promote immune regulation; relieve cancer pain and long-term pain; reduce the myocardial contractility

get vasodilation to achieve antihypertensive effect; and also play an important role in the treatment of anxiety disorder and dermatosis. In the future research on

elegans

it is still necessary to further study the chemical constituents

develop promising lead compounds

conduct in-depth research on its toxicology and clinical pharmacology

and clarify its mechanism of action

make it used more fully and reasonably

and lay the foundation for the application and safe use of

elegans

关键词

Keywords

references

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