五味子活性成分及药理作用研究进展

刘杰; 徐剑; 郭江涛

doi:10.13422/j.cnki.syfjx.20190911

您当前的位置：

首页 >

文章列表页 >

五味子活性成分及药理作用研究进展

综述 | 更新时间：2021-02-09

- 五味子活性成分及药理作用研究进展
- Review of Active Constituents and Pharmacological Activities of Schisandrae Chinensis Fructus
- 中国实验方剂学杂志 2019年25卷第11期页码：206-215
- 作者机构：
  
  贵阳中医药大学，贵阳　 550000
- 作者简介：
  
  刘杰，博士，讲师，从事中药民族药新药及其药效物质基础研究工作，E-mail：271247239@qq.com
  郭江涛，博士，讲师，从事中药药效物质基础及其作用机制研究工作，E-mail：295614500@qq.com
- 基金信息：
  
  贵州省普通高等学校中药民族药（苗药）新剂型新制剂工程研究中心项目(黔教合KY字[2014]22号);贵州省科学技术基金项目(黔科合基础[2018]1013);贵州省苗医药重点实验室项目(黔苗医药K字[2017]103);苗药医学研究协同创新中心项目([2015]05);国家苗药工程技术研究中心项目(2014FU125Q09)
- DOI：10.13422/j.cnki.syfjx.20190911
  中图分类号： R282.6; R284; R22; R289
- 收稿日期：2018-08-10，
  
  网络出版日期：2019-01-18，
  
  纸质出版日期：2019-06-05
- 稿件说明：
移动端阅览
刘杰, 徐剑, 郭江涛. 五味子活性成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(11):206-215.

Jie LIU, Jian XU, Jiang-tao GUO. Review of Active Constituents and Pharmacological Activities of Schisandrae Chinensis Fructus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 206-215.
刘杰, 徐剑, 郭江涛. 五味子活性成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(11):206-215. DOI： 10.13422/j.cnki.syfjx.20190911.

Jie LIU, Jian XU, Jiang-tao GUO. Review of Active Constituents and Pharmacological Activities of Schisandrae Chinensis Fructus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 206-215. DOI： 10.13422/j.cnki.syfjx.20190911.

摘要

五味子(

Schisandra chinensis

)为木兰科植物五味子的干燥成熟果实。近年来，国内外学者对五味子各个部位的活性成分及药理作用进行了大量的研究，表明五味子具有药用和食用的双重功能，被广泛用作保健品和药品。该文对五味子的活性成分及药理作用进行系统地整理，发现五味子果实、种子、根、藤茎、叶等药用部位主要包含木脂素类、挥发油类、三萜类、多糖类及黄酮类化合物，其中木脂素类为五味子中的主要特征性活性成分，三萜类、多糖类及挥发油的活性次之，黄酮类化合物活性鲜有报道。通过对五味子药理学研究发现，五味子木脂素类成分对中枢神经系统、心血管系统、肝脏、肾脏和生殖系统均有一定的影响，且还具有抗氧化、抗肿瘤、抑菌、抗人类免疫缺陷病毒(HIV)的作用。其他化学成分也均具有较好的药理活性，但相比木脂素类，研究深度仍有待挖掘。该研究为开发利用五味子，同时为今后深入开展五味子的药品和保健品提供了重要的参考和基础。

Abstract

Schisandrae Chinensis Fructus is dry

mature fruits of magnolia plant

Schisandra chinensis

. In recent years

domestic and foreign scholars have made a lot of studies on active constituents of

chinensis

and pharmacological activities. This article systematically organizes the active constituents and pharmacological activities of

chinensis

. It was found that fruit

seeds

roots

stems and leaves of

chinensis

and other medicinal parts mainly contained lignans

volatile oils

triterpenoids

polysaccharides and flavonoids. And lignans were the main characteristic active ingredients of

chinensis

triterpenoids

polysaccharides and volatile oils were the secondary active ingredients

and the activity of flavonoids had rarely been reported. According to the pharmacological study of

chinensis

lignans had certain effects on the central nervous system

cardiovascular system

liver

kidney and reproductive system

with anti-oxidation

anti-tumor

anti-bacterial and anti-HIV effects. Other chemical components also had good pharmacological activities

but were less studied than lignans. With dual functions in medicine and food

it was widely used as a health product and medicine. This article systematically summarized the active constituents and pharmacological activities of

chinensis

and provided an important reference and basis for the further development of the health product and medicine of

chinensis

in the future.

关键词

Keywords

references

刘宇灵，付赛，樊丽姣，等．南北五味子化学成分、药理作用等方面差异的研究进展 [J]．中国实验方剂学杂志， 2017 ， 23 ( 12 )： 228 - 234 ．

QIU F , LIU H , DUAN H , et al . Isolation, structural elucidation of three new triterpenoids from the stems and leaves of Schisandra chinensis(Turcz) Baill . [J]. Molecules , 2018 , 23 ( 7 ): 1624 .

刘华，郭江涛，王知斌，等．五味子挥发油中萜类、芳香族和脂肪族化合物的成分分析 [J]．化学工程师， 2016 ， 30 ( 8 )： 27-29，32 ．

HUANG S X , HANG Q B , LEI C , et al . Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis [J]. Tetrahedron , 2008 , 64 ( 19 ): 4260 - 4267 .

胥春霞，刘嫚，陈东林，等．北五味子化学成分的研究 [J]．中成药， 2017 ， 39 ( 3 )： 547 - 550 ．

PARK H Z , LEE S Z , SONG Y , et al . Schisandra chinensis prevents alcohol-induced fatty liver disease in rats [J]. J Med Food , 2014 , 17 ( 1 ): 103 - 110 .

Yiman M , JIAO P , Moore B , et al . Hepatoprotective activity of herbal composition SAL, a standardize blend comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis [J]. J Nutr Metab , 2016 , 2016 : 1 - 10 .

ZHAO T , MAO G H , ZHANG M , et al . Anti-diabetic effects of polysaccharides from ethanol-insoluble residue of Schisandra chinensis(Turcz.) Baill on alloxan-induced diabetic mice [J]. Chem Res Chin Univ , 2013 , 29 ( 1 ): 99 - 102 .

Jang H I , Do G M , Lee H M , et al . Schisandra chinensis Baill on regulates the gene expression of phase Ⅱ antioxidant/detoxifying enzymes in hepatic damage induced rats [J]. Nutr Res Pract , 2014 , 8 ( 3 ): 272 - 277 .

史琳，王志成，冯叙桥．五味子化学成分及药理作用的研究进展 [J]．药物评价研究， 2011 ， 34 ( 3 )， 208 - 212 ．

LU Y , CHEN D F . Analysis of Schisandra chinensis and Schisandra sphenanthera [J]. J Chromatogr A , 2009 , 1216 ( 11 ): 1980 - 1990 .

Kochetkov N K , Khorlin A Y , Chizhov O S , et al . Schizandrin-lignan of unsual structure [J]. Tetrahedron Lett , 1961 , 2 ( 20 ): 730 - 734 .

YANG B Y , GUO J T , LI Z Y , et al . New thymoquinol glycosides and neuroprotective dibenzocyclooctane lignans from the rattan stems of Schisandra chinensis [J]. Chem Biodivers , 2016 , 13 ( 9 ): 1118 - 1125 .

LIU M , HU Z X , LUO Y Q , et al . Two new compounds from Schisandra propinqua var. propinqua [J]. Nat Prod Bioprospect , 2017 , 7 ( 3 ): 257 - 262 .

秦波，田珍，楼之岑．五味子果实中挥发油成分的鉴定 [J]．中国药学杂志， 1988 ， 23 ( 6 )： 338 - 339 ．

LI X N , CUI H , SONG Y Q , et al . Analysis of volatile fractions of Schisandra chinensis(Turcz.) Baill. using GC-MS and chemometric resolution [J]. Phytochem Anal , 2003 , 14 ( 1 ): 23 - 33 .

TENG H , Lee W Y . Antibacterial and antioxidant activities and chemical compositions of volatile oils extracted from Schisandra chinensis Baill. seeds using simultaneous distillation extraction method, and comparison with soxhlet and microwave-assisted extraction [J]. Biosci Biotechnol Biochem , 2014 , 78 ( 1 ): 79 - 85 .

CHEN X , ZHANG Y , ZU Y , et al . Chemical composition and antioxidant activity of the essential oil of Schisandra chinensis fruits [J]. Nat Prod Res , 2012 , 26 ( 9 ): 842 - 849 .

LIU C J , ZHANG S Q , ZHANG J S , et al . Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis(Turcz.) Baill [J]. Nat Prod Res , 2012 , 26 ( 23 ): 2199 - 2203 .

WANG L , CHEN Y , SONG Y , et al . GC-MS of volatile components of Schisandra chinensis obtained by supercritical fluid and conventional extraction [J]. J Sep Sci , 2008 , 31 ( 18 ): 3238 - 3245 .

周英，杨峻山，王立为，等．五味子科植物三萜成分 [J]．中国药学杂志， 2003 ， 38 ( 2 )： 81 - 83 ．

WU W , RUAN H . Triterpenoids and lignans from the stems of Schisandra glaucescens [J]. Nat Prod Res , 2019 , 33 ( 3 ): 328 - 334 .

DING W P , HU K , LIU M , et al . Five new schinortriterpenoids from Schisandra propinqua var. propinqua [J]. Fitoterapia , 2018 , 127 : 193 - 200 .

LIU Y , TIAN T , YU H Y , et al . Nortriterpenoids from the stems and leaves of Schisandra viridis [J]. Fitoterapia , 2017 , 118 : 38 - 41 .

薛梅，周静，王鲁石，等．五味子多糖的提取及含量测定 [J]．陕西中医， 2003 ， 24 ( 3 )： 267 - 268 ．

孟宪军，那广宁，高晓旭，等．北五味子多糖的分离纯化研究 [J]．食品科技， 2008 ， 33 ( 11 )： 197 - 199 ．

CHENG Z , YANG Y , LIU Y , et al . Two-steps extraction of essential oil, polysaccharides and biphenyl cyclooctene lignans from Schisandra chinensis Baill fruits [J]. J Pharm Biomed Anal , 2014 , 96 : 162 - 169 .

CHENG Z , SONG H , YANG Y , et al . Optimization of microwave-assisted enzymatic extraction of polysaccharides from the fruit of Schisandra chinensis Baill [J]. Int J Biol Macromol , 2015 , 76 : 161 - 168 .

刘俊霞，侯微，窦凤鸣，等．五味子藤茎正丁醇部位化学成分研究 [J]．中草药， 2015 ， 46 ( 13 )： 1878 - 1882 ．

金银萍，王英平，王振兴，等．超高效液相色谱法测定不同种质资源五味子藤茎中5种黄酮类成分的含量 [J]．天然产物研究与开发， 2018 ， 30 ( 1 )： 61 - 64 ．

马涛，毛红燕，石太渊，等．辽五味子黄酮纯化及定性光谱分析 [J]．食品与生物技术学报， 2012 ， 31 ( 1 )： 101 - 105 ．

许瑞波，万蓓蓓，高颖颖，等．北五味子叶总黄酮的提取及生物活性 [J]．食品科学， 2013 ， 34 ( 20 )： 72 - 76 ．

Sowndhararajan K , Deepa P , Kim M , et al . An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis [J]. Biomed Pharmacother , 2017 , 97 : 958 - 968 .

ZHU H , ZHANG L , WANG G , et al . Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice [J]. J Food Drug Anal , 2016 , 24 ( 4 ): 831 - 838 .

葛会奇，贾天柱．五味子炮制品镇静催眠作用研究 [J]．辽宁中医杂志， 2007 ， 34 ( 5 )： 636 - 637 ．

YAN T , HE B , WAN S , et al . Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism [J]. Sci Rep , 2017 , 7 ( 1 ): 6903 .

CHI A , ZHANG Y , KANG Y , et al . Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome [J]. Int J Biol Macromol , 2016 , 93 ( Pt A ): 322 - 332 .

E Q , TANG M , ZHANG X , et al . Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells [J]. Cell Biol Int , 2015 , 39 ( 12 ): 1418 - 1424 .

SA F , ZHANG L Q , CHONG C M , et al . Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo [J]. Neurosci Lett , 2015 , 593 : 7 - 12 .

李贺，李宁，刘聪，等．五味子乙素对ICR小鼠的抗焦虑作用及其作用机制 [J]．吉林大学学报：医学版， 2018 ， 44 ( 1 )： 78 - 82 ．

LI N , LIU J , WANG M , et al . Sedative and hypnotic effects of schisandrin B through increasing GABA/Glu ratio and upregulating the expression of GABAA in mice and rats [J]. Biomed Pharmacother , 2018 , 103 : 509 - 516 .

SONG F , ZENG K , LIAO L , et al . Schizandrin A inhibits microglia-mediated neuroninflammation through inhibiting TRAF6-NF-κB and Jak2-Stat3 signaling pathways [J]. PLoS One , 2016 , 11 ( 2 ): e0149991 .

ZHANG C , MAO X , ZHAO X , et al . Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABA ergic system [J]. Fitoterapia , 2014 , 96 : 123 - 130 .

WANG X , YU J , LI W , et al . Characteristics and antioxidant activity of lignans in Schisandra chinensis and Schisandra sphenanthera from different locations [J]. Chem Biodivers , 2018 , doi: 10.1002/cbdv.201800030 http://doi.org/10.1002/cbdv.201800030 .

KANG J S , HAN M H , Kim G Y , et al . Schisandrae Semen essential oil attenuates oxidative stress-induced cell damage in C2C12 murine skeletal muscle cells through Nrf2-mediated upregulation of HO-1 [J]. Int J Mol Med , 2015 , 35 ( 2 ): 453 - 459 .

ZHAO X , LIU C , XU M , et al . Total lignans of Schisandra chinensis ameliorates aβ1-42-induced neurodegeneration with cognitive impairment in mice and primary mouse neuronal cells [J]. PLoS One , 2016 , 11 ( 4 ): e0152772 .

YAN T , SHANG L , WANG M , et al . Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats [J]. Metab Brain Dis , 2016 , 31 ( 3 ): 653 - 661 .

YANG B Y , HAN W , HAN H , et al . Effects of lignans from Schisandra chinensis rattan stems against aβ1-42-induced memory impairment in rats and neurotoxicity in primary neuronal cells [J]. Molecules , 2018 , 23 ( 4 ): 1 - 12 .

Kim J S , Jeong S H , Han S H , et al . Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells [J]. Clin Exp Pharmacol Physiol , 2018 , 45 ( 6 ): 547 - 555 .

XIN D Q , HU Z M , HUO H J , et al . Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats [J]. Mol Med Rep , 2017 , 16 ( 1 ): 533 - 538 .

Kim D S , Irfan M , Sung Y Y , et al . Schisandra chinensis and morus alba synergistically inhibit in vivo thrombus formation and platelet aggregation by impairing the glycoprotein Ⅵ pathway [J]. Evid Based Complement Alternat Med , 2017 , 2017 : 7839658 .

Jeong J W , Kim J W , KU S K , et al . Essential oils purified from Schisandrae Semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells [J]. BMC Complement Altern Med , 2015 , 15 : 7 .

SUN J H , LIU X , CONG L X , et al . Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans in diet-induced hyperlipidemia mice [J]. Lipids Health Dis , 2017 , 16 ( 1 ): 145 .

ZHANG W , SUN Z , MENG F , et al . Schisandrin B ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis [J]. Inflammation , 2017 , 40 ( 6 ): 1903 - 1911 .

WU J , JIA J , LIU L , et al . Schisandrin B displays a protective role against primary pulmonary hypertension by targeting transforming growth factor β1 [J]. J Am Soc Hypertens , 2017 , 11 ( 3 ): 148 - 157 .

Thandavarayan R A , Giridharan V V , Arumugam S , et al . Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling [J]. PLoS One , 2017 , 10 ( 3 ): e0119214 .

ZHANG M , LIU M , XIONG M , et al . Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy [J]. J Ethnopharmacol , 2012 , 141 ( 1 ): 111 - 118 .

ZHAI J , ZHANG F , GAO S , et al . Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain [J]. J Ethnopharmacol , 2018 , 210 : 223 - 231 .

LI Y Z , REN S , YAN X T , et al . Improvement of cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects [J]. J Ethnopharmacol , 2018 , 217 : 228 - 237 .

郭冷秋，张鹏，黄莉莉，等．五味子药理作用研究进展 [J]．中医药学报， 2006 ， 34 ( 4 )： 51 - 53 ．

原丽欣．五味子乙素对顺铂所致大鼠肾氧化损伤的保护作用 [J]．中国医院药学杂志， 2014 ， 34 ( 10 )： 825 - 828 ．

LI F , ZHANG T , SUN H , et al . A new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of Schisandra chinensis [J]. Molecules , 2017 , 22 ( 11 ): 1 - 8 .

Park H J , Lee S J , SONG Y , et al . Schisandra chinensis prevents alcohol-induced fatty liver disease in rats [J]. J Med Food , 2014 , 17 ( 1 ): 103 - 110 .

Chung M Y , Shin E J , Choi H K , et al . Schisandra chinensis berry extract protects against steatosis by inhibiting histone acetylation in oleic acid-treated HepG2 cells and in the livers of diet-induced obese mice [J]. Nutr Res , 2017 , 46 : 1 - 10 .

WANG C M , YUAN R S , ZHUANG W Y , et al . Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice [J]. Lipids Health Dis , 2016 , 15 ( 1 ): 195 .

朱力杰．北五味子总三萜、木脂素对酒精性肝损伤的保护作用及其机制的研究 [D]．沈阳：沈阳农业大学， 2014 ．

LI B , ZHU L , WU T , et al . Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats [J]. Cell Biochem Biophys , 2015 , 71 ( 2 ): 803 - 811 .

YUN Y R , Kim J H , Kim J H , et al . Protective effects of gomisin N against hepatic steatosis through AMPK activation [J]. Biochem Biophys Res Commun , 2017 , 482 ( 4 ): 1095 - 1101 .

CHEN Q , ZHANG H , CAO Y , et al . Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways [J]. Drug Des Devel Ther , 2017 , 11 : 2179 - 2191 .

LI X , SUN J , FAN X , et al . Schisandrol B promotes liver regeneration after partial hepatectomy in mice [J]. Eur J Pharmacol , 2018 , 818 : 96 - 102 .

ZENG H , JIANG Y , CHEN P , et al . Schisandrol B protects against cholestatic liver injury through pregnane X receptors [J]. Br J Pharmacol , 2017 , 174 ( 8 ): 672 - 688 .

ZHENG N , LIU F , LU H , et al . Schisantherin A protects against liver ischemia-reperfusion injury via inhibition of mitogen-activated protein kinase pathway [J]. Int Immunopharmacol , 2017 , 47 : 28 - 37 .

QU H M , LIU S J , ZHANG C Y , et al . Antitumor and antiangiogenic activity of Schisandra chinensis polysaccharide in a renal cell carcinoma model [J]. Int J Biol Macromol , 2014 , 66 : 52 - 56 .

LIU S J , QU H M , REN Y P , et al . SCP, a polysaccharide from Schisandra chinensis, induces apoptosis in human renal cell carcinoma Caki-1 cells through mitochondrial-dependent pathway via inhibition of ERK activation [J]. Tumour Biol , 2014 , 35 ( 6 ): 5369 - 5374 .

赖一鸣，许娜，陈晓杰，等．五味子多糖抑制卵巢癌SKOV3细胞增殖的研究 [J]．中华中医药学刊， 2014 ， 32 ( 4 )： 856-857，968 ．

丁振东，张玉影，张宇，等．五味子多糖对脑肿瘤干细胞的凋亡诱导及生长抑制作用 [J]．吉林大学学报：医学版， 2018 ， 44 ( 2 )： 305-309，465 ．

Jeong M , Kim H M , Kim H J , et al . Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells [J]. Arch Pharm Res , 2017 , 40 ( 4 ): 500 - 508 .

LI F , ZHANG T , SUN H , et al . A new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of Schisandra chinensis [J]. Molecules , 2017 , 22 ( 11 ): 1931 .

上官梦原，赵菁，陈俊宇，等．五味子脂A增强卡铂对人卵巢癌Skov3细胞的促凋亡作用及其机制 [J]．吉林大学学报：医学版， 2018 ， 44 ( 1 )： 83-89，207 ．

张媛媛，李艳利，李书国．五味子抑菌成分的提取及在面制食品保鲜中的应用 [J]．粮食与饲料工业， 2014 ， 12 ( 6 )： 23 - 27 ．

闫绍悦，林树乾，傅剑，等．五味子提取液抑菌活性研究 [J]．中国实验方剂学杂志， 2014 ， 20 ( 10 )： 142 - 146 ．

Mocan A , Crisan G , Vlase L , et al . Comparative studies on polyphenolic composition, antioxidant and antimicrobial activities of Schisandra chinensis leaves and fruits [J]. Molecules , 2014 , 19 ( 9 ): 15162 - 15179 .

YI H , CHEN Y , LIU J , et al . Extraction and separation of active ingredients in Schisandra chinensis(Turcz.) Baill and the study of their antifungal effects [J]. PLoS One , 2017 , 11 ( 5 ): e0154731 .

GUO M , AN F , WEI X , et al . Comparative effects of schisandrin A, B, and C on acne-related inflammation [J]. Inflammation , 2017 , 40 ( 6 ): 2163 - 2172 .

Hakala E , Hanski L L , Yrjönen T , et al . The lignan-containing extract of Schisandra chinensis berries inhibits the growth of chlamydia pneumonia [J]. Nat Prod Commun , 2015 , 10 ( 6 ): 1001 - 1004 .

Hakala E , Hanski L , Uvell H , et al . Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis [J]. J Antibiot(Tokyo) , 2015 , 68 ( 10 ): 609 - 614 .

XU J , LU C , LIU Z , et al . Schizandrin B protects LPS-induced sepsis via TLR4/NF-κB/MyD88 signaling pathway [J]. Am J Transl Res , 2018 , 10 ( 4 ): 1155 - 1163 .

MU H X , LI X S , FAN P , et al . Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities [J]. J Asian Nat Prod Res , 2011 , 13 ( 5 ): 393 - 399 .

YANG G Y , LI Y K , ZHANG X J , et al . Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities [J]. Nat Prod Bioprospect , 2011 , 1 ( 1 ): 33 - 36 .

DUAN Y X , CAO J L , WEN R R , et al . Dibenzocyclooctadiene lignans from Schisandra neglecta and their anti-HIV-1 activities [J]. J Asian Nat Prod Res , 2011 , 7 ( 13 ): 592 - 598 .

XU L , Grandi N , Del V C , et al . From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors [J]. J Microbiol , 2015 , 53 ( 4 ): 288 - 293 .

ZHONG S , NIE Y C , GAN Z Y , et al . Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure [J]. J Ethnopharmacol , 2015 , 165 : 73 - 82 .

HONG S H , LI M , Jeung E B , et al . Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat [J]. Int J Oncol , 2017 , 50 ( 4 ): 1448 - 1454 .

Kwan H Y , WU J , SU T , et al . Schisandrin B regulates lipid metabolism in subcutaneous adipocytes [J]. Sci Rep , 2017 , 7 ( 1 ): 10266 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

重楼皂苷Ⅱ的药理作用、药代动力学及不良反应研究进展

淫羊藿抗肝癌活性成分及作用机制研究进展

紫苏叶挥发油化学成分及其药理作用研究进展

辣木叶活性成分及其药理作用研究进展

艾叶挥发油类成分及其药理作用的研究进展