1.河南中医药大学 第一附属医院,郑州 450000
2.黑龙江中医药大学,哈尔滨 150040
陈言,在读博士,从事常见功能障碍中医康复的临床与基础研究,E-mail:cy15937179269@163.com
冯志海,教授,主任中医师,硕士生导师,从事中医药防治内分泌疾病的研究,E-mail:13607649136@163.com
收稿:2024-11-19,
修回:2025-03-04,
录用:2025-04-02,
网络首发:2025-04-21,
纸质出版:2026-03-20
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陈言,代婷,郭长胜等.基于PI3K/Akt信号通路探讨中医药治疗肌肉减少症的研究进展[J].中国实验方剂学杂志,2026,32(06):316-326.
CHEN Yan,DAI Ting,GUO Changsheng,et al.TCM Treatment of Sarcopenia Based on PI3K/Akt Signaling Pathway: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(06):316-326.
陈言,代婷,郭长胜等.基于PI3K/Akt信号通路探讨中医药治疗肌肉减少症的研究进展[J].中国实验方剂学杂志,2026,32(06):316-326. DOI: 10.13422/j.cnki.syfjx.20251492.
CHEN Yan,DAI Ting,GUO Changsheng,et al.TCM Treatment of Sarcopenia Based on PI3K/Akt Signaling Pathway: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(06):316-326. DOI: 10.13422/j.cnki.syfjx.20251492.
肌肉减少症是一种系统性骨骼肌疾病,表现为肌肉质量、力量和功能的逐渐下降,其发生发展与多种因素相关,涉及多条信号通路。其中,磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路作为调节细胞生长、存活和代谢等生物过程的关键通路,在肌肉减少症的形成与发展中发挥了重要作用,其异常激活或失活可能引起肌肉蛋白质代谢失衡,进而导致肌肉萎缩和减少。现代医学对肌肉减少症的治疗仍在探索阶段,中医药以其多途径、多靶点的特点,在肌肉减少症的预防和治疗方面展现出日益突出的优势。近年来,多种中药单体、提取物及中药复方等被证实能够通过促进肌蛋白合成、减少肌蛋白降解、抑制细胞凋亡和炎症反应、改善线粒体功能等机制,有效预防和治疗肌肉减少症。该文基于PI3K/Akt信号通路,综述了中医药对肌肉减少症的改善作用,探讨其具体作用机制,以期为中医药治疗肌肉减少症提供新思路。
Sarcopenia is a systemic skeletal muscle disease characterized by the gradual decline of muscle mass,strength,and function,and its occurrence and development are related to multiple factors,involving several signaling pathways. Among them,the phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt) signaling pathway,as a key pathway regulating cellular growth,survival,and metabolism,plays an important role in the formation and development of sarcopenia. Its abnormal activation or deactivation may lead to an imbalance in muscle protein metabolism,resulting in muscle atrophy and reduction. Modern medicine is still in the exploratory stage of treatment for sarcopenia. Traditional Chinese medicine (TCM),with its multi-pathway and multi-target characteristics,has shown increasing advantages in the prevention and treatment of sarcopenia. In recent years,various monomers, extracts,and compound formulas of TCM have been proven to effectively prevent and treat sarcopenia by promoting muscle cell protein synthesis,reducing protein degradation,inhibiting cell apoptosis and inflammatory response,and improving mitochondrial function. This paper reviewed the improvement effects of TCM on sarcopenia based on the PI3K/Akt pathway and explored its specific action mechanisms, aiming to provide new insights for the treatment of sarcopenia with TCM.
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