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Action Mechanism of Betulinic Acid in Inhibiting Ferroptosis and Improving Non-alcoholic Fatty Liver Disease Based on Bioinformatics and Experimental Validation
Updated：2026-07-16
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    • Action Mechanism of Betulinic Acid in Inhibiting Ferroptosis and Improving Non-alcoholic Fatty Liver Disease Based on Bioinformatics and Experimental Validation

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    • “Betulinic acid may inhibit iron death process, alleviate liver inflammation and lipid deposition by regulating GPX7, LTF, and S100A8. Its mechanism is related to restoring GPX4 activity and downregulating ACSL4 expression. The research team has provided a new target for the development of NAFLD therapeutic drugs through bioinformatics analysis combined with animal experiments.”
    • TANG Gaojun , HU Jie , LUO Li , WU Huan , ZHANG Quan , ZHANG Baofang
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 16, Pages: 160-169(2026)

    • DOI： 10.13422/j.cnki.syfjx.20250519     

      CLC：

    • Revised：2025-05-05 ，

      Accepted：06 May 2025 ，

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Related Author

HU Jie
LUO Li
ZHONG Zhu
LI Can
WU Huan
XU Wei
LI Yuanyuan
ZHU Juanjuan

Related Institution

The Affiliated Hospital of Guizhou Medical University
Hebei University of Chinese Medicine
Hebei Key Laboratory of Health Care with Traditional Chinese Medicine（TCM）
Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease
Hebei Higher Education Institute Applied Technology Research Center on TCM Development and Industrialization