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Mechanisms of Celastrus orbiculatus Ethylacetate Extract in Regulating M2 Macrophage Polarization to Inhibit Gastric Cancer Proliferation and Migration
Updated:2026-07-16
    • Mechanisms of Celastrus orbiculatus Ethylacetate Extract in Regulating M2 Macrophage Polarization to Inhibit Gastric Cancer Proliferation and Migration

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    • “The triterpenoids of southern snake vine can inhibit the proliferation and migration ability of gastric cancer cells by regulating the polarization state of macrophages. Its mechanism of action may be closely related to the Toll like receptor 4/nuclear transcription factor - κ B (TLR4/NF - κ B) signaling pathway regulating epithelial mesenchymal transition (EMT) process. The research team explored the intervention strategy of traditional Chinese medicine active ingredients targeting the tumor microenvironment, opening up a new direction for the treatment of gastric cancer.”
    • LI Dan , SHEN Jiacheng , JI Fandi , MASATAKA Sunagawa , WANG Haibo , LIU Yanqing
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 16, Pages: 170-178(2026)
    • DOI: 10.13422/j.cnki.syfjx.20251423     

      CLC:
    • Revised:2025-05-19 ,

      Accepted:20 June 2025 ,

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