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Mechanisms of Celastrus orbiculatus Ethylacetate Extract in Regulating M2 Macrophage Polarization to Inhibit Gastric Cancer Proliferation and Migration
Mechanisms of
Enhanced PublicationCelastrus orbiculatus Ethylacetate Extract in Regulating M2 Macrophage Polarization to Inhibit Gastric Cancer Proliferation and Migration- “The triterpenoids of southern snake vine can inhibit the proliferation and migration ability of gastric cancer cells by regulating the polarization state of macrophages. Its mechanism of action may be closely related to the Toll like receptor 4/nuclear transcription factor - κ B (TLR4/NF - κ B) signaling pathway regulating epithelial mesenchymal transition (EMT) process. The research team explored the intervention strategy of traditional Chinese medicine active ingredients targeting the tumor microenvironment, opening up a new direction for the treatment of gastric cancer.”
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 16, Pages: 170-178(2026)
DOI: 10.13422/j.cnki.syfjx.20251423
Revised:2025-05-19 ,
Accepted:20 June 2025
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Related Author
LIU Yanqing
LI Chao
WANG Shihui
LIN Jie
WANG Fanke
ZHANG Rui
SHI Peizheng
XIAO Shanshan
Related Institution
Affiliated Hospital of Yangzhou University, Yangzhou First People's Hospital
The First Hospital of Hebei Medical University
School of Basic Medical Sciences, Guangzhou University of Chinese Medicine
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences


