“The incidence rate of insomnia is increasing year by year, and the imbalance of neurotransmitters is one of the core pathological mechanisms. This article reviews the research progress of traditional Chinese medicine in regulating brain neurotransmitters to treat insomnia in recent years. With the integrated regulation mode of "multi-component multi-target multi pathway", traditional Chinese medicine has shown unique advantages in restoring neurotransmitter balance and improving sleep quality, providing a solution to the problem of chemical drug dependence.”