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Mechanisms of Zuojinwan in Inhibiting Tumor-associated Macrophage M2 Polarization Against Colorectal Cancer Through Regulation of TIPE1/PI3K/Akt Signaling Pathway
Updated：2026-09-17
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    • Mechanisms of Zuojinwan in Inhibiting Tumor-associated Macrophage M2 Polarization Against Colorectal Cancer Through Regulation of TIPE1/PI3K/Akt Signaling Pathway

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    • “Zuojin Wan may inhibit the proliferation and migration of colorectal cancer by suppressing the transformation of tumor associated macrophages M2. Researchers have established an AOM/DSS colorectal cancer mouse model and co cultured it with CT26/RAW264.7 to explore the mechanism of Zuojin Wan targeting TIPE1 protein to regulate the PI3K/Akt signaling pathway, providing a new target for traditional Chinese medicine anti-tumor immunotherapy.”
    • NONG Feifei , XING Shangping , DENG Shuye
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 20, Pages: 22-32(2026)

    • DOI： 10.13422/j.cnki.syfjx.20251627     

      CLC：

    • Revised：2025-07-21 ，

      Accepted：28 July 2025 ，

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Related Author

NONG Feifei
DENG Shuye
GUO Meixuan
LIN Yuxing
CAI Mengyuan
SHEN Aling
LU Wen
LI Li

Related Institution

Experimental Center of Traditional Chinese Medicine and Ethnic Medicine， The First Affiliated Hospital of Guangxi University of Chinese Medicine
Guangxi Key Laboratory of Preventive Medicine and Molecular Biology， The First Affiliated Hospital of Guangxi University of Chinese Medicine
Institute of Integrative Medicine，Fujian University of Traditional Chinese Medicine
Key Laboratory of Geriatric Diseases Integrative Medicine of Fujian Province
Provincial Clinical Medical College， Fujian Medical University