“New progress has been made in the research of Chinese medicine monomer regulating iron death of Schwann cells to interfere with diabetes peripheral neuropathy, and its research progress in the field of DPN treatment was introduced. Researchers explored the mechanism of saponins, flavonoids, polyphenols and polysaccharides to inhibit iron death of SCs by regulating iron metabolism, enhancing antioxidant capacity and repairing cell damage, providing a new strategy for DPN treatment.”