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Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway
Updated:2026-02-28
    • Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway

    • “The latest research has found that the XZP formula for relieving symptoms and pain significantly inhibits astrocyte pyroptosis by regulating the PINK1/Parkin mediated mitochondrial autophagy NLRP3 inflammasome pathway, effectively alleviating bone cancer pain and providing a new mechanism for related treatments.”
    • WANG Lingyun , ZHENG Guangda , SHANG Lu , REN Juanxia , LI Changlin , LI Dongtao , LIU Haixiao , CHEN Yaohua , YANG Guiping , BAO Yanju
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 5, Pages: 80-90(2026)
    • DOI: 10.13422/j.cnki.syfjx.20251932     

      CLC:
    • Revised:2025-10-07 ,

      Accepted:13 October 2025 ,

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Related Author

WANG Lingyun
SHANG Lu
REN Juanxia
LI Changlin
CHEN Yaohua
YANG Guiping
GAO Xingxing
GU Ying

Related Institution

The First Clinical College, Liaoning University of Traditional Chinese Medicine
Xining Hospital of Traditional Chinese Medicine
The First Affiliated Hospital of Hebei University of Chinese Medicine
College of Pharmacy, Hebei University of Chinese Medicine, International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine(TCM)
Department of Pharmacy, Shijiazhuang Medical College