Xiaozheng Zhitong Paste Relieves Bone Cancer Pain in Mice by Alleviating Activation of Microglia in Spinal Cord and Damage to Neurons via Blocking PAR2/NF-κB/NLRP3 Pathway

ZHENG Guangda; MENG Linghan; SHANG Lu; REN Juanxia; LI Dongtao; LIU Haixiao; WANG Lingyun; LI Changlin; CHEN Yaohua; YANG Guiping; BAO Yanju

doi:10.13422/j.cnki.syfjx.20251934

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Xiaozheng Zhitong Paste Relieves Bone Cancer Pain in Mice by Alleviating Activation of Microglia in Spinal Cord and Damage to Neurons via Blocking PAR2/NF-κB/NLRP3 Pathway

Updated：2026-02-28

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- Xiaozheng Zhitong Paste Relieves Bone Cancer Pain in Mice by Alleviating Activation of Microglia in Spinal Cord and Damage to Neurons via Blocking PAR2/NF-κB/NLRP3 Pathway
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- “The latest research has found that XZP, a topical formula for relieving symptoms and pain, has significant therapeutic effects on bone cancer pain (BCP). The study established a BCP mouse model and found that XZP can alleviate BCP in mice. Its therapeutic effect may be achieved by blocking the expression of the activated PAR2/NF - κ B/NLRP3 signaling pathway.”
- ZHENG Guangda , MENG Linghan , SHANG Lu , REN Juanxia , LI Dongtao , LIU Haixiao , WANG Lingyun , LI Changlin , CHEN Yaohua , YANG Guiping , BAO Yanju
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 5, Pages: 91-100(2026)
- Affiliations：
  1.Guang'anmen Hospital，China Academy of Chinese Medical Sciences， Beijing 100053，China
  2.Liaoning University of Traditional Chinese Medicine， Shenyang 110847，China
  3.Xining Traditional Chinese Medicine Hospital，Xining 810001，China
- Author bio：
- Funds：
- DOI： 10.13422/j.cnki.syfjx.20251934
  CLC：
- Revised：2025-10-13 ，
  Accepted：20 October 2025 ，
- Accepted：
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Related Author

ZHENG Guangda

YANG Guiping

BAO Yanju

CHEN Yaohua

LI Changlin

WANG Lingyun

ZHENG Guangda

REN Juanxia

Related Institution

China Academy of Chinese Medical Sciences

Xining Municipal Hospital of TCM

Liaoning University of Traditional Chinese Medicine（TCM）

Xining Municipal Hospital of Traditional Chinese Medicine

Xining Hospital of Traditional Chinese Medicine

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Xiaozheng Zhitong Paste Relieves Bone Cancer Pain in Mice by Alleviating Activation of Microglia in Spinal Cord and Damage to Neurons via Blocking PAR2/NF-κB/NLRP3 Pathway

DOI： 10.13422/j.cnki.syfjx.20251934

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