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Xiaozheng Zhitong Paste Alleviates Bone Cancer Pain of Mice by Reducing Ferroptosis in Spinal Cord Tissue and Neuronal Damage via Regulating Nrf2/HO-1/GPX4/SLC7A11 Signaling Pathway
Updated：2026-02-28
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    • Xiaozheng Zhitong Paste Alleviates Bone Cancer Pain of Mice by Reducing Ferroptosis in Spinal Cord Tissue and Neuronal Damage via Regulating Nrf2/HO-1/GPX4/SLC7A11 Signaling Pathway

    • “The latest research has found that XZP, an external formula for relieving symptoms and pain, can alleviate bone cancer pain (BCP). Experts have established a mouse BCP model and found that XZP can activate the Nrf2/HO-1/GPX4/SLC7A11 pathway, inhibit spinal neuron ferroptosis and injury, alleviate pain symptoms, and provide new ideas for the treatment of bone cancer pain.”
    • REN Juanxia , SHANG Lu , ZHENG Guangda , MENG Linghan , WANG Lingyun , LI Changlin , LI Dongtao , CHEN Yaohua , YANG Guiping , BAO Yanju
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 5, Pages: 101-113(2026)

    • DOI： 10.13422/j.cnki.syfjx.20252038     

      CLC：

    • Revised：2025-10-25 ，

      Accepted：27 October 2025 ，

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Related Author

SHANG Lu
REN Juanxia
WANG Lingyun
LI Changlin
CHEN Yaohua
YANG Guiping
BAO Yanju
ZHENG Guangda

Related Institution

Liaoning University of Traditional Chinese Medicine（TCM）
Xining Municipal Hospital of TCM
Xining Traditional Chinese Medicine Hospital
Xining Municipal Hospital of Traditional Chinese Medicine
China Academy of Chinese Medical Sciences