“Diabetes nephropathy (DKD) is a chronic kidney disease caused by diabetes, which seriously endangers the health of patients. Research has found that apoptosis plays a key role in the occurrence and development of DKD, involving abnormal activation of multiple signaling pathways. Traditional Chinese medicine has demonstrated significant therapeutic effects in the treatment of DKD due to its advantages of multi-target, multi-component, and multi pathway approaches. Experts conduct in-depth analysis of the apoptotic signaling pathway and its regulatory mechanisms, review the latest research progress of traditional Chinese medicine intervention in DKD, provide new strategies for delaying the progression of DKD, and promote the widespread application of traditional Chinese medicine in this field.”