“Parkinson's disease (PD) is a chronic progressive neurodegenerative disease characterized by motor dysfunction as the main clinical manifestation. Its main pathological features include the loss of dopaminergic neurons in the substantia nigra of the midbrain, abnormal aggregation of alpha synuclein (α - Syn), and formation of Lewandowski bodies. Its pathogenesis is not yet fully understood. In recent years, the incidence rate of PD has gradually increased, and the current treatment can only improve its symptoms, can not prevent the disease from progressing, and has many adverse reactions. Therefore, it is urgent to find effective drugs to treat PD. Modern research has shown that the Kelch like ECH related protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is closely related to oxidative stress, neuroinflammation, cell apoptosis, iron death, and mitochondrial dysfunction, and plays a key role in the pathological and physiological development of PD. Numerous studies have further confirmed that traditional Chinese medicine can regulate diseases through holistic differentiation and micro molecular pathways, and has unique advantages such as multi-target, multi pathway, and fewer adverse reactions, providing new strategies for the treatment of PD. This article elaborated the mechanism of the Keap1/Nrf2/ARE signaling pathway in the occurrence and development of PD, and summarized the latest research on the intervention of the traditional Chinese medicine monomer and effective ingredients, compound and acupuncture and moxibustion precisely targeted regulation of the Keap1/Nrf2/ARE signaling pathway in PD, with a view to providing reference for the development of clinical drugs for prevention and treatment of PD. Rewrite: This article introduces the research progress in the field of Parkinson's disease (PD), and experts explore the mechanism of Keap1/Nrf2/ARE signaling pathway in the occurrence and development of PD, providing reference for the development of clinical drugs for the prevention and treatment of PD.”