“Cardiovascular disease is the main cause of death worldwide. Heart failure (HF) is the end stage of many cardiovascular diseases, with high incidence rate and mortality characteristics, and has become a major global public health challenge. This paper introduced its research progress in the field of ginsenoside intervention. Relevant teams explored the protective effects of ginsenosides on HF and key targets, which opened up a new direction for in-depth research on the pathogenesis of HF and drug development.”