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Fangji Fulingtang Attenuates Myocardial Fibrosis by Regulating Mitochondrial Function Through AMPK/PGC-1α/MFN2-PKM2 Signaling Pathway
Updated：2026-09-17
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    • Fangji Fulingtang Attenuates Myocardial Fibrosis by Regulating Mitochondrial Function Through AMPK/PGC-1α/MFN2-PKM2 Signaling Pathway

    • “Fangji Fuling Tang can activate the adenosine monophosphate activated protein kinase (AMPK)/PGC-1 α/MFN2 signaling pathway, inhibit abnormal activation of the PKM2/LDHA/HIF-1 α signaling pathway, restore myocardial mitochondrial function and energy metabolism homeostasis, and improve isoproterenol (ISO) - induced myocardial fibrosis. A Chinese research team has explored a new mechanism of traditional Chinese medicine compound for preventing and treating myocardial fibrosis, providing a new target for the treatment of myocardial fibrosis.”
    • DU Xuqin , LI Yixuan , JIN Yuxia , LI Hongding , YANG Ruogu , SHI Lipeng , REN Yi
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 20, Pages: 1-10(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260442     

      CLC：

    • Revised：2026-02-27 ，

      Accepted：04 March 2026 ，

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SHI Lipeng
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Related Institution

College of Traditional Chinese Medicine（TCM）， Chongqing Medical University
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