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Xiaoyaosan Combined with Fuzi Lizhongwan Reduces High-fat Diet-induced Depressive-like Behavior in Rats with Spleen Deficiency by Regulating Mitochondrial Energy Metabolism and Glycolysis Reprogramming
Updated：2026-07-16
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    • Xiaoyaosan Combined with Fuzi Lizhongwan Reduces High-fat Diet-induced Depressive-like Behavior in Rats with Spleen Deficiency by Regulating Mitochondrial Energy Metabolism and Glycolysis Reprogramming

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    • “The combination of Xiaoyao San and Fuzi Lizhong Wan can synergistically regulate mitochondrial energy metabolism and glycolysis reprogramming, restore energy homeostasis, and alleviate inflammatory reactions. The research team has established a rat model of high-fat diet depression like behavior under the background of spleen deficiency, opening up a new direction for traditional Chinese medicine in the prevention and treatment of metabolism related depression.”
    • ZHONG Zhen , WEI Dongsheng , XIONG Xinyue , LI Lin , YAO Mingli , SHI Xinnuan , Amir Hooman Kazemi , JIANG Youming
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 16, Pages: 92-106(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260616     

      CLC：

    • Revised：2026-05-05 ，

      Accepted：09 May 2026 ，

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Related Author

ZHANG Meng
WANG Meixia
ZHAO Qian
ZHANG Yu
CHEN Yimin
ZHANG Yanyun
XIAO Chunfeng
GONG Peishuai

Related Institution

The First Afffiliated Hospital of Anhui University of Chinese Medicine
Graduate School of Anhui University of Chinese Medicine
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Elderly Brain Health Chinese Medicine Protection Technology and New Product Development Engineering Research Center of the Ministry of Education， Hubei University of Chinese Medicine
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