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Hei Xiaoyaosan Reduces Neuroinflammation in APP/PS1 Mice via CX3CL1-CX3CR1 Signaling Axis
Updated：2026-10-16
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    • Hei Xiaoyaosan Reduces Neuroinflammation in APP/PS1 Mice via CX3CL1-CX3CR1 Signaling Axis

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    • “Black Xiaoyao Powder can improve the learning and cognitive abilities of APP/PS1 mice, and its mechanism of action may be related to targeted regulation of the CX3CL1/CX3CR1 signaling axis to activate the CREB/BDNF signaling pathway. The research team has validated a new target of traditional Chinese medicine compound intervention in neuroinflammation of Alzheimer's disease, opening up new directions for the prevention and treatment of neurodegenerative diseases with traditional Chinese medicine.”
    • LYU Yujie , YANG Jiao , HU Yunyun , MENG Zhipeng , CHEN Yiqin , PEI Wenli , HAN Yumei , WANG Huping
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 22, Pages: 83-90(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260638     

      CLC：

    • Revised：2026-04-01 ，

      Accepted：03 April 2026 ，

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Related Author

YANG Jiao
CHEN Yiqin
PEI Wenli
HAN Yumei
WANG Huping
ZHOU Jun
LI Mingcheng
LYU Yujie

Related Institution

Gansu Engineering Laboratory for New Products of Traditional Chinese Medicine （TCM）， Gansu Key Laboratory of TCM Excavation and Innovative Transformation，Gansu University of Chinese Medicine
Xichang Hospital of TCM，Xichang
Qujing 69 Hospital，China RongTong Medical Healthcare Group Co.， Ltd.
Xingtai Hospital of TCM
Zhengzhou TCM Hospital Affiliated to Henan University of Chinese Medicine