“The pathological mechanism of ischemic stroke is complex, and there are many adverse drug reactions in clinical practice. Huangqi, as a classic Chinese medicine for replenishing qi, is widely used in the prevention and treatment of ischemic stroke. This article introduces its research progress in the field of ischemic stroke prevention and treatment. The research team systematically sorted out the core pathological links of IS, summarized the main active ingredients of Huangqi, classic drug pairs, and representative compound brain protective effects, providing a systematic theoretical reference for the clinical application and new drug development of Huangqi and its combination in IS.”