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Simiaosan Reduces Podocyte Apoptosis in Obese Rats with Hyperuricemia via GRP78/CHOP-endoplasmic Reticulum Stress Axis
Updated：2026-07-16
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    • Simiaosan Reduces Podocyte Apoptosis in Obese Rats with Hyperuricemia via GRP78/CHOP-endoplasmic Reticulum Stress Axis

    • “Simiao San can improve renal function and podocyte injury in obese rats with hyperuricemia. Its mechanism may be related to inhibiting the PERK/eIF2 α/ATF4/CHOP signaling pathway mediated by GRP78 and reducing endoplasmic reticulum stress-induced podocyte apoptosis. The research team explored the molecular mechanism of traditional Chinese medicine compound intervention in metabolic nephropathy, providing a new target for the prevention and treatment of obesity with hyperuricemia.”
    • WANG Xu , ZHAO Zhuo , LI Jiayun , JIANG Xu , HOU Yingying , LI Jia , LIU Ziyu , YANG Xiao
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 16, Pages: 50-59(2026)

    • DOI： 10.13422/j.cnki.syfjx.20260805     

      CLC：

    • Revised：2026-05-04 ，

      Accepted：15 May 2026 ，

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Related Author

HOU Yingying
ZHAO Zhuo
WANG Xu
LI Jiayun
JIANG Xu
LI Jia
LIU Ziyu
YANG Xiao

Related Institution

Shenyang Key Laboratory of Research and Transformation of Novel Traditional Chinese Medicine for Immune Inflammatory Diseases
The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Liaoning Institute of Traditional Chinese Medicine
Liaoning University of Traditional Chinese Medicine
Hebei University of Chinese Medicine