“Huanglian decoction may alleviate esophageal mucosal damage by regulating the imbalance of esophageal microbiota structure and improving abnormal bile acid metabolism. Its mechanism of action may be closely related to regulating "esophageal microbiota bile acid metabolism". The research team established a rat model of reflux esophagitis and explored the therapeutic mechanism of Huanglian decoction, opening up a new direction for traditional Chinese medicine treatment of gastrointestinal diseases.”