“Huangqi Guizhi Wuwu Tang was first recorded in Zhang Zhongjing's "Synopsis of the Golden Chamber" during the Eastern Han Dynasty. It is the main formula for treating blood stasis and has the effects of nourishing qi, warming meridians, and promoting blood circulation. The research progress of Huangqi Guizhi Wuwu Tang in the field of treating different diseases with the same treatment was introduced. This formula regulates multiple signaling pathways such as NF - κ B/NLRP3 and Nrf2/ARE, providing evidence-based basis and ideas for the modern transformation and precise application of classic formulas in chronic muscle and bone stasis syndrome.”