Bin SUN, Wen-shan LIU, Hong-kun LI, et al. Effect of Traditional Chinese Medicine in Regulating Immune Mechanism of Chronic Urticaria. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):206-211(2019)
DOI:
Bin SUN, Wen-shan LIU, Hong-kun LI, et al. Effect of Traditional Chinese Medicine in Regulating Immune Mechanism of Chronic Urticaria. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(22):206-211(2019) DOI: 10.13422/j.cnki.syfjx.20191430.
Effect of Traditional Chinese Medicine in Regulating Immune Mechanism of Chronic Urticaria
Chronic urticaria (CU) is one of common diseases of dermatology. It has the clinical characteristics of allergy
multiple
recurrent and persistent recovery. The clinical symptoms of patients are mainly pruritus and wheal
and concurrent with vascular edema
some patients may even suffer from chest tightness
nausea and other systemic symptoms. Its pathogenesis is still unclear
and it is generally considered to be related to autoimmune
chronic infection
coagulation mechanism
vitamin D deficiency and so on. Among them
autoimmunity may be one of the important causes for chronic urticaria. Clinical studies mostly focus on immunoglobulin E
T cell subsets CD4
+
T cells
CD8
+
T cells
cytokines interleukin-2
interferon-
γ
and complement C3
C4. Western medicine therapies mostly use antihistamines. The first generation of antihistamines have an obvious inhibitory effect on central nervous system
and side reactions
such as sedative and anticholinergic Effect. Although the second generation has a reduced inhibitory effect on central nervous system
it is easy to cause heart toxicity and relapse after drug withdrawal. Therefore
it is particularly important to find a safe and effective traditional Chinese medicine(TCM) therapy. Urticaria belongs to the category of " hidden rashes" in TCM. The etiology and pathogenesis are insufficient endowment of body elements
insufficient external defense or improper diet
damp-heat connotation. Classic prescriptions and self-prepared formulas
such as Jade Screen Powder
shall be used in the treatment of phlegm and blood stasis
with a clear clinical effect and a low recurrence rate. In addition
by reducing the level of immunoglobulin E in patients
improving CD4
+
T cells
CD8
+
T cell levels
regulating the levels of related cytokines
increasing the levels of complement C3
C4
these therapies could reduce IgE levels
release of anaphylatoxins
stimulation of mast cells and inflammatory reactions
and regulate the body's immune function
with a satisfactory efficacy. Therefore
the author has summarized the clinical researches on the mechanism of traditional Chinese medicine in regulating chronic urticaria in past five years.
关键词
慢性荨麻疹免疫机制中药调节
Keywords
chronic urticariaimmune mechanismtraditional Chinese medicine (TCM)regulate
references
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